Anti-Inflammatory Effect of Selected Dihydroxyflavones FF05-FF07
Professor, Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra University,
Porur, Chennai – 6000115, Tamilnadu, India.
E-mail : firstname.lastname@example.org
Background: The mechanism of inflammation is attributed, to release of reactive oxygen species from activated neutrophils and macrophages. Over production of reactive oxygen species may result in tissue injury by damaging macromolecules. Flavones are the polyphenolic compounds with antioxidant property. This antioxidant property of flavones may have beneficial effect against inflammation.
Aim: To study the anti-inflammatory effect of selected dihydroxyflavones (DHF) in albino rats. The prime objective of the present study is to identify safe and effective agents to treat inflammation from among the selected DHF group of compounds.
Materials and Methods: The present study was designed to investigate the anti-inflammatory action of four selected dihydroxyflavone derivatives; 2’,3’- dihydroxyflavone and 2’, 4’ -dihydroxyflavones, 5, 3’- dihydroxyflavone and 7, 3’ dihydroxyflavone. The anti-inflammatory activity of selected DHF was studied in rats by carrageenan induced hind paw oedema method.
Results: All the selected dihydroxyflavone derivatives showed dose and time dependent inhibition of carrageenan induced paw oedema.