Surrogate Markers of the Kidney and Liver in the Assessment of Gestational Diabetes Mellitus and Fetal Outcome OC14-OC17
Dr. Shao-Gang Ma,
Faculty, Department of Endocrinology and Metabolism, Huaiâ€™an Hospital Affiliated to Xuzhou
Medical College and Huaiâ€™an Second Peopleâ€™s Hospital, Huaiâ€™an 223002, China.
Introduction: To investigate whether serum levels of butyrylchoÂ linesterase activity, cystatin C, and pre albumin has the potential value as ? glutamyl transferase in reflecting gestational diabetes mellitus and its fetal outcome.
Materials and Methods: Seventy six gestational diabetes mellitus women and 76 pregnancies with normal glucose tolerance in the second trimester were enrolled. Maternal serum parameters of butyrylcholinesterase activity, ? glutamyl transferase, cystatin C, and pre albumin were detected and evaluated. The pregnant complications and fetal outcome were also evaluated.
Results: Levels of butyrylcholinesterase activity, ? glutamyl transferase, cystatin C, pre albumin and glycemic variables were higher in the gestational diabetes mellitus patients than in the controls. Levels of butyrylcholinesterase activity were significantly correlated to the levels of fasting plasma glucose, cystatin C, and ? glutamyl transferase ( p < 0.05) in the gestational diabetes mellitus group. There were statistical differences in cases of preterm delivery, preeclampsia and postpartum hemorrhage. Higher levels of ? glutamyl transferase and pre albumin were risk markers for gestational diabetes mellitus ( p < 0.05). The diagnosis curve demonstrated that ? glutamyl transferase had a significant advantage over other markers ( p < 0.001) but no significance compared with pre albumin ( p = 0.096). None of the detected markers showed predictive value for fetal outcome.
Conclusion: Serum levels of butyrylcholinesterase activity, ? glutamyl transferase, cystatin C and pre albumin were corÂ related with gestational diabetes mellitus status but not with the fetal outcome. Pre albumin can be equivalent as ? glutamyl transferase in reflecting the presence of gestational diabetes mellitus.