Influence of Grape Seed Extract and Zinc Containing Multivitamin-Mineral Nutritional Food Supplement on Lipid Profile in Normal and Diet-Induced Hypercholesterolemic Rats
HC12-HC15
Correspondence
Dr. Laxminarayana Kurady Bairy,
Professor and Head of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka, India.
Phone : - 0820-2922365, Fax : 0820-2922083, E-mail : klbairy@gmail.com
Background: Zincovit tablet is combination of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement. Aims: To investigate the influence of single combined formulation of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement tablets (Zincovit) on lipid profile in normal and diet-induced hypercholesterolemic rats.
Materials and Methods: Anti-hyperlipidemic activity of combined formulation of grape seed extract and Zincovit tablets doses ranged from 40 to 160 mg/kg, p.o. was evaluated in normal and diet-induced hypercholesterolemic rats.
Results: Hypercholesterolemic animals treated with combined formulation of grape seed extract and Zincovit tablets (nutritional food supplement) at 40, 80 and 160 mg/kg exhibited drastic decrease in serum triglycerides, total cholesterol, LDL-C, VLDL-C and rise of HDL-C in comparison to hypercholesterolemic control group animals. The anti-hyperlipidemic effect of single combined formulation of grape seed extract and Zincovit tablet was comparable with the standard drug atorvastatin treated animals and the variations were statistically non-significant. There was no significant impact of combined formulation of grape seed extract and Zincovit tablets on lipid profile among normal animals in comparison with normal control group.
Conclusion: The present study demonstrated that the single combined formulation of grape seed extract and Zincovit tablet is the potential functional nutritional food supplements that could offer a novel therapeutic opportunity against diet-induced hypercholesterolemia in Wistar rats.