The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction 817-820
Dr. Ramesh Ramasamy,
Professor & Head, Department of Biochemistry,
Mahathma Gandhi Medical College and Research
Institute Pillayarkuppam Puducherry - 605 402, India.
Tel: +91 â€“ 4132615449, Extension- 602
Fax: +91 - 0413 -2615457
Background: Ischemic heart disease accounts 12.2% deaths worldwide. Serum magnesium (Mg+) status is often ignored in Acute Myocardial Infarction (AMI). Studies showed alterations in the levels of serum electrolytes including magnesium in AMI.
Aim: To evaluate serum Mg+ and other electrolytes as adjuvant markers in the diagnosis of AMI.
Design and Settings: Case control study was conducted in South Indian male population with AMI within six hours of onset of symptoms.
Patients and Methods: Study includes sixty patients with AMI and 100 controls. Serum electrolytes were estimated using electrolyte analyzer. Data were compared by using studentâ€˜tâ€™ test. ROC was drawn to find out optimum cutoff for diagnosing AMI. Pearsonâ€™s correlation was done to see the association among the markers.
Results: Serum Ca, Mg, K and Na electrolytes were significantly lower (â€˜pâ€™<0.001) in AMI. Ca:Mg, K:Mg, and Na:K ratios were significantly higher when compared to controls (â€˜pâ€™<0.001). There was significant correlation of serum Mg levels with other cardiac markers (Total CK, CKâ€“Mb, Troponin â€“T) of AMI (â€˜pâ€™ <0.05).ROC analysis of Na:Mg (40.9), Ca:Mg (3.43) and K:Mg (2.74) ratios showed optimum cutoffs in diagnosis of AMI.
Conclusion: Serum Mg, Ca:mg, K:mg and Na:K ratios could be useful adjuvant markers in diagnosis of AMI.