Serum 25(OH)D and Type 2 Diabetes Mellitus
Dr. Balasubramanian Shanthi,
Associate Professor, Department of Biochemistry,
Balaji Medical College And Hospital, Clc Works Road Chrompet
Phone : 9884025026.
25(OH) Vitamin D is the circulating form of vitamin D which is measurable in the blood. Vitamin D insufficiency has been defined as serum 25-hydroxyvitamin D (25(OH) D) levels below 30 ng/mL and it is common among patients with type 2 diabetes mellitus (DM).
Aim and Objectives:
Our aim was to investigate the clinically meaningful associations which implicated low serum levels of 25(OH) D with impaired diabetic control in DM type 2.
The serum 25(OH) D and the HbA1c levels were determined in 50 patients with DM type 2, along with their FBS, PPBS and HBA1c and other parameters which were required to assess the diabetic control were also measured.
The results of our study revealed a trend towards an inverse vitamin D - FBS (Pearson correlation, r = -0.090) and inverse vitamin D â€“ PPBS (Pearson correlation, r = -0.095) association. The lower serum 25(OH) D levels were associated with the higher HbA1c levels (Pearson correlation, r = -0.173). This was a borderline association which may have probably occurred due to the small sample size.
The association between the low serum 25(OH) D levels and elevated HBA1c in the study population may be inscribed into a wider context, portraying vitamin D insufficiency as a poor prognostic factor, which may play a vital role in impairing the glycaemic control.