The Pattern of the Initial Anti-retroviral Drug Regimens in HIV Patients at a Tertiary
Dr. Mukta N Chowta,
Associate Professor, Department of Pharmacology,
Kasturba Medical College, Light House Hill Road,
Mangalore-575001Manipal University, India.
Phone: 0825-2431122, 9448790524,
Background and objective: The choice of the anti-retroviral drug therapy has been evolving over the last decade. The objective of this study was to evaluate the current prescribing pattern of the anti-retroviral drugs in treatment-na├»ve patients before initiating the anti-retroviral therapy.
Materials and Methods: A retrospective review of the antiretroviral drugs which had been prescribed to the HIV-infected patients was conducted at a tertiary care hospital in South India. Only adults patients who were of more than 18 years of age, with a positive serology, who had started or had already been receiving the anti-retroviral therapy were included. Their main demographics, the details of the AIDS diagnoses, the laboratory data (CD4 cell counts) and the history of the antiretroviral therapy were collected.
Result: The total number of patients was 108. Among them, 76 (70.4%) were males and 32 (29.6%) were females. The mean age of the patients was 38.67 ┬▒10.02years, the mean weight was 52.47┬▒ 11.2kg and the mean CD4 count was 256.57 ┬▒ 204.6cells/cumm. Among these patients, 34(31.5%) were on the lamivudine+ zidovudine+ nevirapine regimen, 70(64.8%) were on the lamnivudine + nevirapine+ stavudine regimen (3TC + NVP+ d4T) and 4(3.7%) were on the tenofovir+ emtricitabine +efavirenz regimen. In the first regimen, the mean age of the patients was 39.09 ┬▒9.1years, the mean weight was 51.87┬▒10.7kg and the mean CD4 count was 253.21┬▒177.8cells/cumm. In the second regimen, the mean age of the patients was 38.73 ┬▒10.59 years, the mean weight was 52.37┬▒12.24kg and the mean CD4 count was 262.02┬▒ 221.4 cells /cumm. The comparison of the mean age and the mean CD4 count among the patients in the different regimens did not show any statistical significance.
Conclusion: The most frequently used antiretroviral drug regimen was the 3TC + NVP+ d4T combination. The prescription pattern was quite in contrast to that which was followed in the developed countries. Newer NRTIs were less frequently used.