Mood Disorders and Female Sub Fertility-Any Relationship? A Pilot Study
Associate Professor, Department of Physiology,
Sree Balaji Medical College &Hospital
No.7, CLC Works Road, New Colony,
Chromepet, Chennai-600044, India.
Back Ground: Subfertility, which is clinically defined as the inability in conceiving a child in spite of having unprotected sex within a year, is a common problem which affects 5-10 % of the women. The subfertile women are at their greatest life time risk for mood disorders during their re-productive years. This work was focused on the contribution of depression to subfertility in the status of the menstrual cycle, the number of follicles and the hormonal profiles like oestrogen and FSH. Materials and Method: Fifty subfertile women were included in this study. By using a questionnaire of Beck Depression Inventory, the subjects were divided into two groups, Group 1; subfertility without depression and Group2: subfertility with depression. This study was approved by the institutional ethical committee and a written consent was obtained from all the participants. Trans vaginal ultrasound was performed to measure the number of follicles on the cycle days, 3-10 .The blood sampling which was done to measure the hormones like FSH and oestradiol was also done on the same day of the cycle. Results: The mean age of the subfertile patients with depression was 30 years. The older subfertile patients were more vulnerable to depression than the younger ones. 70% of the subfertile women with depression had irregular cycles with long periods of amenorhoea or oligimenorrhoea. The antral follicles in the size, 2mm-9mm were more in Group 2 and they showed a statistical significance between the two groups. The levels of FSH and E2 were not statistically significant between the groups. Conclusion: No significant differences were found in the FSH and oestrogen levels between the subfertility without depression and the subfertility with depression groups. But the mood disorders or the depression may be associated with the quality and the number of the follicle counts.