The Lipid Peroxidation Product as a Marker of Oxidative Stress in Epilepsy 590-592
Manmohan Krishna Pandey
Assistant professor of Medicine,
Rohilkhand Medical College & Hospital,
Bareilly (U.P.)243001, India.
Context: Free radicals have been implicated in the development of acute and chronic diseases of the brain e.g. Epilepsy, Cerebrovascular diseases, Parkinson’s disease, Alzheimer’s disease, etc. The present study was designed to assess the oxidative stress in epilepsy, since very few of such studies have been designed in human beings.
Aims: To study the level of the lipid peroxidation products i.e. malondialdehyde (MDA) as a marker of oxidative stress in epilepsy patients.
Settings and Design: This case control study had 170 samples which comprised Group I(n-90) patients of epilepsy as the cases, which were compared with Group II (n-80) which were age and sex matched controls.
Methods and Materials: The lipid peroxidation product i.e. MDA formation was estimated by assessing the levels of thio-barbituric acid reactive substances (TBARS) by using spectrophotometry.
Statistical Analysis Used: The statistical analysis was done by using the SPSS software and the results were described by using the unpaired T test and p values.
Results: In the present study, the mean MDA value in Group I (2.38 ±0.31) was significantly raised (p<0.01) than in Group II (2.15±0.36), thus suggesting that the MDA values were raised in epilepsy. The mean MDA level after 1 year of therapy was 2.25±0.25, with a p value of <0.05, thus suggesting a reduction in the oxidative stress with therapy.
Conclusions: The level of the lipid peroxidation is significantly higher in epilepsy as compared to the control and oxidative stress increases which were found with the duration of the epilepsy. The oxidative stress had no significant difference in the males and females. The oxidative stress was found to reduce on adequate antiepileptic therapy.