A Study Of Visual Evoked Potentials In Patients Of Type 2 Diabetes Mellitus 519-522
Department of Physiology,
Government Medical College,
Amritsar, Punjab, India.
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Type-2 diabetes mellitus (DM) is one of the most serious challenges to healthcare, primarily because of the increase in the prevalence of sedentary life styles and obesity. Neuropathies are the common complications of type-2 DM. Abnormalities within the peripheral nervous system are well documented, but however, changes in the central nervous system and particularly their correlation with visual function, have received much less attention. Visual Evoked Potentials (VEPs) can be used to evaluate the disturbances in the CNS with a simple, sensitive and non-invasive methodology.
Aims And Objectives:
To compare the visual evoked potentials in type-2 DM patients with that of healthy controls and to find out any possible correlation with the duration of the disease.
Material And Methods:
The present study was conducted on three groups (30 patients each) of type 2 DM (different durationsof disease) and one group of 30 healthy age and sex matched controls. The patients with reduced visual acuity which was not correctable with lenses or with retinopathy were excluded. VEP was recorded by using pattern reversal stimulation with A PC Based 2ch. RMS EMG EP Mark II Machine. The peak latencies N70, P100 and N155 and the peak to peak amplitudes N70- P100 and P100-N155 of the waves were measured.
Our results showed significantly prolonged N70 and P100 latencies in diabetic patients and also a significant correlation between the delay in the P100 latency and the duration of the disease.
Abnormalities in the VEP response occur in diabetic patients before the development of overt retinopathy. So, VEP measurements can be used for the early diagnosis of central neuropathy to offer an early opportunity for proper management.