A comparative assessment of the ADR profile in various
anti-cancer regimens excluding gastro-intestinal and
haematological toxicity at a tertiary care centre.
M. K. Vijayalaxmi M.B.B.S., MD
Dept. of Pharmacology, Fr. Muller Medical College,
Mangalore â€“ 575 002,
Ph: 2436301 â€“ 10 lines
Mob : 9845237418
This study compared the adverse drug reaction (ADR) profile in various anti-cancer regimens in 55 patients who attended a tertiary care centre. The adverse drug reactions which are caused by anticancer agents are common and they may be enhanced when the drugs are used in combinations. The cases which conformed to the inclusion criteriae were selected and the details were noted in a proforma, which were then statistically analyzed.
The results which were obtained, showed that the ADRs were common, but that they occurred in a similar frequency as in otherstudy groups and that the severity grade was low. The counter measures to tackle the adverse reactions were also effective, leading to a hundred percent survival through the six cycles and the two year survival, which in itself spoke volumes about the ADRs. These findings were in tune with the findings of various researchers in the field of anti cancer toxicity profiles.
The incidence of the neurotoxicity, the dermatological adverse effects and other miscellaneous ADRs was frequent, but not of high severity.