Sarcomatoid Carcinoma of Prostate with Alveolar Rhabdomyosarcomatous Pattern 1009-1012
Dr. Misra V ProfessorDepartment of Pathology
M.L.N. Medical College,Allahabad - 211 001 (INDIA)
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Sarcomatoid carcinoma (carcinosarcoma) is a rare type of prostatic cancer, composed of an admixture of malignant glandular and spindle cell elements. We report here a case of a 56 year old male who underwent prostatectomy for the symptoms of bladder outlet obstruction.. Histopathology showed small areas of poorly formed glands admixed with large areas of purely alveolar pattern and rossettes. A provisional diagnosis of sarcomatoid carcinoma with alveolar rhabdomyosarcomatous pattern (Gleasonâ€™s score 5+4=9/10) was made. These two patterns led to a diagnostic dilemma between primary alveolar rhabdomyosarcoma of prostate, sarcomatoid carcinoma with rhabdomyosarcomatous pattern and mixed tumour of prostate. On immunohistochemistry, a positive staining for cytokeratin and negative staining for desmin, myogenin and myoD-1, led to a diagnosis of sarcomatoid carcinoma with rhabdomyosarcomatous pattern.The case was considered worth documentation, as it describes an alveolar rhabdomyosarcomatous pattern in a sarcomatoid carcinoma of the prostate. The correct diagnosis of such a case is important, as it may affect the treatment and prognosis of the patient.