Estimation of the Diagnostic Value of Myeloperoxidase Index and Lactate Dehydrogenase in Megaloblastic Anaemia 380-384
Dr Jamal Eivazi-Ziaei. Tabriz University Hematology & Oncology Research Center, Shahid Ghazi Ward, Imam Hospital, Tabriz University of Medical Sciences, Tabriz, P.O. Box. 51665-158, Iran.Email: email@example.com
Background: Most cases of megaloblastic anaemia corresponded to anaemia with hyper-segmented neutrophils, macro-ovalocytosis and very high serum lactate dehydrogenase (LDH) level. Elevated neutrophil myeloperoxidase index (MPXI) may be indicative of a diagnosis of megaloblastic anaemia.
Study Setting and Design: The aim of this study was to estimate the value of MPXI and LDH in the diagnosis of megaloblastic anaemia to facilitate the diagnosis prior to performing any bone marrow aspirate.
Methods: MPXI and LDH were measured using the first blood sample obtained prior to any transfusion or medical therapy and after therapy in 29 patients diagnosed as megaloblastic anaemia. MPXI was assessed using complete blood count (CBC), performed by Technicon H1 (Bayer) automated cell counter.
Results: Mean value of MPXI significantly decreased after treatment (20.4, CI 95%: 17â€“23 vs. 0.75, CI 95%: 4 to 2.7, before and after treatment, respectively). The same significant pattern was also observed for LDH (4230, CI 95%: 3096â€“5369 vs. 783, CI 95%: 492â€“1075, before and after treatment, respectively). The proportional diagnostic value was significantly higher when both MPXI and LDH were used together in the diagnosis of megaloblastic anaemia (83%, P < 0.001), while the same index was 71% (P < 0.001) for MPXI and 48% (P < 0.001) for LDH, respectively, when they were used alone.
Conclusion: MPXI and LDH values may have a diagnostic role on megaloblastic anaemia. It might be used as a reliable screening tool before doing any other diagnostic procedure.