Solitary Plasmocytoma of Bone 61-64
Dr. Karuna Rameshkumar, Department of Clinical Pathology St.Johnâ€™s Medical college Hospital
Email: karuna ramesh
Within the plasma cell dyscrasias, solitary plasmacytoma is rare. Solitary plasmacytoma of bone (SPB) is defined as a single bony lesion caused by a monoclonal plasma cell infiltrate, with no evidence of myeloma elsewhere.
All cases reported as multiple myeloma/plasmacytoma, from January 1999 to August 2002 at St. Johnâ€™s Medical College and Hospital, were reviewed. After applying the diagnostic criteria, three cases conformed to the diagnosis of solitary plasmacytoma (7.5%). In the three cases of SPB, two occurred in males and one in female. The site of occurrence was in the thoracic vertebrae. Although radiotherapy alone is considered adequate, as two patients presenting in the vertebral region had neurological dysfunction, laminectomy was done in addition to radiotherapy. Light microscopy of all three cases showed a dense infiltrate of sheets of plasma cells.
The present study highlights the salient features of SPB. The frustrating aspect in the management of the SPB is the development of peripheral neuropathy, which was present in all three cases and was the presenting symptom in two of the cases as part of POEMS syndrome. Careful microscopy is required in EMP, as it can be confused with other malignancies, particularly lymphomas.