A Preclinical Study On The Gastric Ulcer Protective Activity Of The World’s Hottest Chilli, Capsicum Frutescenes 1024-1027
Dr. Deka S, Department of pharmacology
Assam Medical College & Hospital Dibrugarh Assam ,Pin:786002 ,phone :+91-9954484551 email â€“email@example.com
Objective: To evaluate the ulcer protective activity of the ethanolic extract of Capsicum Frutescenes (EECF) and Ranitidine on aspirin induced gastric ulcer on albino rats.
Materials and Methods: Four groups of albino rats were taken for the study (n=6): Group I was taken as normal control (3% gum acacia orally for 7 days ),Group II as experimental control (3% gum acacia orally for 7 days),Group III (EECF 100mg/kg for 7 days ),Group IV (150 mg/kg ranitidine for 7 days).On the 7th day, the Groups II,III and IV received aspirin (400mg/kg ) as a single dose . After 24 hours of aspirin administration; pyloric ligation was done in all animal Groups and they were kept for 4 hours .Thereafter, the rats were sacrificed and their stomachs were removed to measure the(i) ulcer index (ii)pepsin activity (iii)gastric mucus (iv) free acidity (v) total acidity and (vi)gastric volume
Results : One way analysis of variance (ANOVA) followed by Dunnettâ€™s multiple comparison test, were used for statistical analysis of the results. Values of p < 0.05 were considered significant. The ulcer index, pepsin activity, and free and total acidity showed a significant decrease (p<.05), whereas, there was increase in gastric mucus secretion in Groups III and IV . The reverse was seen in group II.
Conclusion : The study showed that capsicum frutescenes has an ulcer protective effect similar to that of Ranitidine.