Year :
2024
| Month :
April
| Volume :
18
| Issue :
4
| Page :
OC10 - OC14
Full Version
Correlation Between Portal Vein Diameter and
Clinical Prognostic Scores in Patients with
Liver Cirrhosis: A Cross-sectional Study
Published: April 1, 2024 | DOI: https://doi.org/10.7860/JCDR/2024/64705.19294
Aman Garg, Kamal Singh, Nidhi Bhardwaj, Narinder Kaur
1. Senior Resident, Department of General Medicine, Government Medical College and Hospital, Chandigarh, India.
2. Professor, Department of General Medicine, Government Medical College and Hospital, Chandigarh, India.
3. Associate Professor, Department of General Medicine, Government Medical College and Hospital, Chandigarh, India.
4. Professor, Department of Radiodiagnosis, Government Medical College and Hospital, Chandigarh, India.
Correspondence Address :
Dr. Nidhi Bhardwaj,
Associate Professor, Department of General Medicine, Government Medical College and Hospital, Chandigarh-160017, India.
E-mail: drnidhibhardwaj@gmail.com
Abstract
Introduction: Patients with liver cirrhosis develop portal hypertension, which leads to complications like splenomegaly, ascites, and oesophageal varices. Hepatic Venous Pressure Gradient (HVPG) measurement, the best available method to measure portal hypertension, is invasive and difficult to perform. Some studies suggest that an increased Portal Vein Diameter (PVD) on ultrasonography indicates portal hypertension and correlates with oesophageal varices. Studies correlating PVD with other complications of portal hypertension, like ascites and spleen size, are scarce.
Aim: To correlate ultrasonographically measured PVD with clinical prognostic models: Child-Turcotte-Pugh (CTP) score and Model for End-stage Liver Disease (MELD), as well as with platelet count, in patients with liver cirrhosis.
Materials and Methods: This was a cross-sectional study conducted in the Department of General Medicine in collaboration with the Department of Radiodiagnosis at Government Medical Collge, Chandigarh, India, from February 2021 to September 2021 over an eight-month period in a tertiary healthcare centre in North India. A total of 97 patients with cirrhosis, identified based on clinical features supported by laboratory tests and ultrasonography, were included in the study. A 6 mL of blood sample was collected from each patient for haemogram, biochemical tests (liver function tests and renal function tests), and coagulogram. Ultrasonography assessment of PVD, spleen size, and ascites was performed in a supine position using a right subcostal approach, after overnight fasting. The collected data were analysed using relevant statistical tests.
Results: The mean age of the study population was 47.39 ± 12.64 years, with 73 (75.3%) males and 24 (24.7%) females. The most common aetiological factor for liver cirrhosis was alcohol, present in 52 (53.6%) patients. The mean PVD was found to be 12.31±2.71 mm. The correlation coefficient of PVD with spleen size was 0.3 with a p-value of 0.004, suggesting a positive correlation. The correlation coefficient of parameters like thrombocytopenia, CTP score, and MELD score was -0.2 (p-value=0.066), 0.1 (p-value=0.463), and 0.0 (p-value=0.725), respectively.
Conclusion: Sonographically measured PVD cannot be used as a substitute for the clinical grading and staging of cirrhosis. Only a weak positive correlation was found between PVD and spleen size.
Keywords
Child-Turcotte-Pugh score, Model for end-stage liver disease, Portal hypertension, Thrombocytopenia, Ultrasonography
DOI: 10.7860/JCDR/2024/64705.19294
Date of Submission: Apr 13, 2023
Date of Peer Review: Dec 30, 2023
Date of Acceptance: Feb 10, 2024
Date of Publishing: Apr 01, 2024
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Apr 15, 2023
• Manual Googling: Jan 04, 2024
• iThenticate Software: Feb 08, 2024 (14%)
ETYMOLOGY: Author Origin
EMENDATIONS: 6
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