Year :
2016
| Month :
September
| Volume :
10
| Issue :
9
| Page :
ZE18 - ZE21
Full Version
Molecular Classification of Oral Squamous Cell Carcinoma
Published: September 1, 2016 | DOI: https://doi.org/10.7860/JCDR/2016/19967.8565
Radhika Manoj Bavle, Reshma Venugopal, Paremala Konda, Sudhakara Muniswamappa, Soumya Makarla
1. Editor-in-Chief, Journal of Oral and Maxillofacial Pathology, Professor and Head of Department, Department of Oral and Maxillofacial Pathology,
Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru, Karnataka, India.
2. Lecturer, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru, Karnataka, India.
3. Reader, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru, Karnataka, India.
4. Reader, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru, Karnataka, India.
5. Reader, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru, Karnataka, India.
Correspondence Address :
Dr. Reshma Venugopal,
Lecturer, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences and Hospital,
Sir MVIT campus, Hunasamarenahalli, off New International Airport Road, via Yelahanka,
Bengaluru-562157, Karnataka, India.
E-mail: reshmav132@gmail.com
Abstract
Oral Squamous Cell Carcinoma (OSCC) is the commonest tumour in the oro-facial region with increasing incidence in the recent years. The disease is challenging as it still depicts a high morbidity and mortality rate. Clinico-pathological data, tumour site, pathologic site tumor, lymphnode, metastasis (TNM) staging, histological grade, invasion, perineural invasion and metastasis have been evaluated to a great depth in relation to OSCC. Co-morbidity factors like use of tobacco, alcohol consumption and various other factors including genetic predisposition have been looked at for finding a suitable treatment protocol. The crux of the matter in understanding the complexity of oral cancer lies in the biological heterogeneity of the tumour. Similar heterogeneity is seen in clinical presentation, histopathology and molecular changes at the cellular level. In spite of the disease being diagnosed, a prediction of the same related to behaviour has remained elusive. Hence, it is time to look beyond at the genetic and epigenetic events leading to molecular and cytogenetic changes that elucidate the pathogenesis and help in design and implementation of targeted drug therapy. A molecular classification of OSCC needs to be put in place much before a clinician can design the treatment protocol of the same and predict the prognosis.
Keywords
Cancer biology, Epigenetics, Gene expression, Gene therapy/therapeutics
DOI: 10.7860/JCDR/2016/19967.8565
Date of Submission: Mar 06, 2016
Date of Peer Review: May 12, 2016
Date of Acceptance: Jun 14, 2016
Date of Publishing: Sep 01, 2016
Financial OR OTHER COMPETING INTERESTS: None.
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