Year :
2013
| Month :
June
| Volume :
7
| Issue :
6
| Page :
982 - 986
Full Version
The Efficacy of Nardostachys Jatamansi Against The Radiation Induced
Haematological Damage in Rats
Published: June 1, 2013 | DOI: https://doi.org/10.7860/JCDR/2013/.3078
Damodara K M Gowda, Lathika Shetty, Krishna A P, Suchetha N Kumari, Ganesh Sanjeev, Naveen P
1. Lecturer, Department of Physiology, K.S.Hegde Medical
Academy, Nitte University, Karnataka-575018, India.
2. Professor, Department of Radiology, K.S.Hegde Medical
Academy, Nitte University, Karnataka-575018, India.
3. Professor, Department of Physiology, K.S.Hegde Medical
Academy, Nitte University, Karnataka-575018, India.
4. Professor, Department of Biochemistry, K.S. Hegde
Medical Academy, Nitte University, Karnataka-575018,
India.
5. Senor Physicist, Department of Physics, Mangalore
University, Karnataka, India.
6. Research Assistant, Central Research Laboratory, Nitte
University, Karnataka-575018, India.
Correspondence Address :
Dr. Damodara Gowda K M,
Lecturer, Department of Physiology,
K.S. Hegde Medical Academy, Nitte University,
Karnataka-575018, India.
Phone: 09886003776
E-mail: damodar001@gmail.com
Abstract
Introduction: Radiation is increasingly being used for medical purposes and it is an established weapon in the diagnosis and the therapy of cancer. An exposure to 1-2 Gys causes the NVD (Nausea, vomiting, diarrhoea) syndrome, whereas an exposure to 2-6 Gys causes the haematopoietic syndrome. The aim of the present study was to investigate the protective effect of the Nardostachys jatamansi root extract (NJE) on the radiation induced haematological damage in rats.
Materials and Methods: EBR was performed at the Microtron Centre, Mangalore University, India. Rats were treated with NJE once daily for 15 days before and after the irradiation. After the irradiation, blood was collected for determining the peripheral blood counts (RBC and WBC), haemoglobin, the platelet count and the packed cell volume (PCV) at 6 hours, 12 hours, 24 hours, 48 hours and 5, 10 and 15 days post irradiation. The data was analyzed by one way ANOVA, followed by the Tukey’s test for multiple comparisons.
Result: NJE provided protection against the radiation induced haematological disorders. The rats treated with NJE exhibited a time dependent significant elevation in all the haematological parameters which were studied and its modulation upto the near normal level was recorded.
Conclusion: From this study, we concluded that, NJE provides protection by modulating the radiation induced damage on the haematopoietic system.
Keywords
Whole body irradiation, Electron beam irradiation, Peripheral blood counts, Platelet
count, Packed cell volume, CFU Assay, Splenic index
Introduction
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DOI: 10.7860/JCDR/2013/5475.3078
Financial OR OTHER COMPETING INTERESTS:
None.
Date of Submission: Dec 17, 2012
Date of Peer Review: Feb 15, 2013
Date of Acceptance: Mar 24, 2013
Date of Online Ahead of Print: Apr 26, 2013
Date of publishing: Jun 01, 2013
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