Year :
2021
| Month :
February
| Volume :
15
| Issue :
2
| Page :
ED03 - ED05
Full Version
Giant Cell Tumour of Clivus: A Rare Case Report
Published: February 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/47359.14534
Swapan Shantiram Goswami, Sonal Jain, Shalin Nagori
1. Professor, Department of Pathology, Smt. B.K. Shah Medical College, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India.
2. Second Year Resident, Department of Pathology, Smt. B.K. Shah Medical College, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India.
3. Second Year Resident, Department of Pathology, Smt. B.K. Shah Medical College, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India.
Correspondence Address :
Dr. Shalin Nagori,
113, Gargi Sumandeep Vidyapeeth, Vadodara, Gujarat, India.
E-mail: shalinnagori07@gmail.com
Abstract
Giant Cell Tumours (GCT) of the skull is rare, being less than 0.05% of all skeletal tumours. They are usually located in the middle cranial fossa affecting the temporal, sphenoid, petrosal and occipital bone. Clival GCT is rarer and 15 cases are described in the literature. Authors report a case of a female patient aged 20 years, who complained of headache with decrease in vision of left eye. Neurological examination revealed left optic nerve palsy. Laboratory test of Vitamin B12, blood urea, Serum Creatinine, Serum Electrolytes were within normal range. Complete blood count showed mild anaemia. The serum calcium and parathyroid hormones were within normal range. Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI) were done, which demonstrated expansile destructive lytic lesion involving sphenoid bone and clivus, reaching upto sellar, parasellar regions, sphenoid sinus and left posterior ethmoid sinus, effacing left optic foramina and posteriorly effacing prepontine cistern. The left internal carotid artery was partially encased by the mass. The tumour was partially removed by endoscopic trans-nasal trans-sphenoidal approach. Histopathology confirmed it as a benign GCT. Surgical treatment of clival GCTs are fraught with complication because of its close proximity to vital structures. High vascularity, potential malignant behaviour, inaccessibility and very few published cases preclude a definite outcome of this lesion. Histopathology is necessary to differentiate various lytic lesion like chordoma, aneurysmal bone cyst, invasive pituitary adenoma, chondrosarcoma and brown tumour (parathyroidism).
Keywords
Left optic nerve palsy, Osteoclastoma, Skull base tumour
10.7860/JCDR/2021/47359.14534
Date of Submission: Oct 23, 2020
Date of Peer Review: Nov 25, 2020
Date of Acceptance: Jan 09, 2021
Date of Online Ahead of Print: Jan 29, 2021
Date of Publishing: Feb 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? No
• For any images presented appropriate consent has been obtained from the subjects. No
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Oct 27, 2020
• Manual Googling: Jan 08, 2021
• iThenticate Software: Jan 23, 2021 (2%)
ETYMOLOGY: Author Origin
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