Year :
2021
| Month :
February
| Volume :
15
| Issue :
2
| Page :
EC01 - EC02
Full Version
Efficacy of D-Dimer Assay in Pulmonary Venous Thromboembolism: Study of 76 Cases
Published: February 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/47331.14486
Shubhi Saxena, Nishant Saxena, Richa Jain, Jasmin Jasani
1. Assistant Professor, Department of Pathology, Smt. BK Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara,
Gujarat, India.
2. Senior Resident, Department of Cardiology, Smt. BK Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara,
Gujarat, India.
3. Assistant Professor, Department of Pathology, Smt. BK Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara,
Gujarat, India.
4. Professor, Department of Pathology, Smt. BK Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.
Correspondence Address :
Dr. Nishant Saxena,
E6, Staff Quarters, Sumandeep Vidyapeeth, Piparia, Waghodia Road,
Vadodara, Gujarat-391760, India.
E-mail: nsaxena014@gmail.com
Abstract
Introduction: Venous Thromboembolism (VTE) encompasses a wide spectrum consisting predominantly of deep venous thrombosis and pulmonary embolism. The value of Fibrin Degradation Product (FDP) of which, most common is D-dimer which is most commonly deployed to pre-diagnose venous thrombosis. Diagnosing it has always been a hard effort. It is produced when cross-linked fibrin is broken down; among patient who is suspected of having pulmonary embolism, blood D-dimer levels correlate with the probability of having pulmonary embolism.
Aim: This study was done to analyse the sensitivity of plasma D-dimer for VTE.
Materials and Methods: Retrospective case study of 76 patients with VTE in form of pulmonary embolism done at the Dhiraj Hospital, Sumandeep Vidyapeeth Deemed University, Vadodara from January 2019 to January 2020 for a period of one year. Prethrombolytic plasma was withdrawn and D-dimer quantification were measured using fully automatic stago coagulometer instruement (STA Compact Max). Sensitivity, Specificity, Negative Predictive Value (NPV) and Positive Predictive Value (PPV) was calculated and formulated in tables and graphs.
Results: The sensitivity, NPV, specificity and PPV of the D-dimer was 95.65%, 76.92%, 66.66% and 92.95%, respectively. CT pulmonary angiography had a specificity of 80%, sensitivity of 92.75%, a NPV of 70.58% and a PPV of 95.52%.
Conclusion: D-dimer is mostly the go to test for ruling out VTE especially pulmonary embolism, if the pre-test probability is intermediate. Rationale use of this test does help in prognostification and helps to achieve therapeutics faster and more effectively.
Keywords
Deep venous thrombosis, Pulmonary angiography, Pulmonary embolism
DOI: 10.7860/JCDR/2021/47331.14486
Date of Submission: Oct 23, 2020
Date of Peer Review: Nov 19, 2020
Date of Acceptance: Jan 01, 2021
Date of Publishing: Feb 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? NA
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Oct 26, 2020
• Manual Googling: Dec 30, 2020
• iThenticate Software: Jan 15, 2021 (6%)
ETYMOLOGY: Author Origin
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