Year :
2020
| Month :
October
| Volume :
14
| Issue :
10
| Page :
OC15 - OC17
Full Version
Effect of Haemodialysis on QTc in Newly Diagnosed Chronic Kidney Disease Patients
Published: October 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/45428.14113
Siddharth Gosavi, TV Pradeep, Amogh Ananda Rao, Sissmol Davis, Bharat Pulavarti, Prathyaksh P Vaishnav
1. Postgraduate Resident, Department of General Medicine, JJM Medical College, Davangere, Karnataka, India.
2. Associate Professor, Department of General Medicine, JJM Medical College, Davangere, Karnataka, India.
3. Intern Medical Officer, Department of General Medicine, JJM Medical College, Davangere, Karnataka, India.
4. Intern Medical Officer, Department of General Medicine, JJM Medical College, Davangere, Karnataka, India.
5. Intern Medical Officer, Department of General Medicine, JJM Medical College, Davangere, Karnataka, India.
6. Intern Medical Officer, Department of General Medicine, JJM Medical College, Davangere, Karnataka, India.
Correspondence Address :
Siddharth Gosavi,
Medical College Road, MCC B Block, Davangere-577004, Karnataka, India.
E-mail: ramshyamsid@gmail.com
Abstract
Introduction: Cardiovascular disease and mortality is twice as common in patients with Chronic Kidney Disease (CKD) compared to the general population. The QT interval which depicts ventricular repolarisation, is a crude non-invasive marker of susceptibility to ventricular arrhythmias. Effects of haemodialysis on corrected QT (QTc) interval in newly diagnosed CKD patients is undocumented till date.
Aim: To assess the effect of haemodialysis on QTc in patients with newly diagnosed CKD.
Materials and Methods: This was a prospective cohort study of 50 newly diagnosed CKD patients admitted for their first session of haemodialysis in the Departments of General Medicine and Nephrology, at Bapuji Hospital between October and November 2019. ECGs were recorded before the first and after the third session of haemodialysis. Serum electrolytes (sodium, potassium, chloride, phosphorous and calcium), blood sugar and haemoglobin levels before haemodialysis were recorded. QT interval was calculated and corrected using Bazett’s and Framingham’s methods. Descriptive statistics, simple and multiple linear regression were used for analysis using Microsoft® Excel.
Results: The mean predialysis QTc was 0.434 seconds and postdialysis QTc was 0.477 seconds. QTc prolongation was observed in 44 (88%) patients (mean=0.042 seconds). The QTc prolongation correlated positively with postdialysis QTc (p=0.00001, Framingham; p=0.0009, Bazett) (RBazett=0.61 and RFramingham=0.74).
Conclusion: Substantial QTc prolongation after three sessions of haemodialysis screens a population that has a greater risk of adverse cardiovascular events. This warrants vigilant cardiac monitoring in patients on haemodialysis.
Keywords
Arrhythmia, Chronic renal failure, Dys-electrolytemia, QT interval, QT prolongation
DOI: 10.7860/JCDR/2020/45428.14113
Date of Submission: Jun 10, 2020
Date of Peer Review: Jul 02, 2020
Date of Acceptance: Sep 07, 2020
Date of Publishing: Oct 01, 2020
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Jun 11, 2020
• Manual Googling: Sep 02, 2020
• iThenticate Software: Sep 22, 2020 (11%)
ETYMOLOGY: Author Origin
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