Year :
2020
| Month :
August
| Volume :
14
| Issue :
8
| Page :
EC12 - EC17
Full Version
Intrathyroid Parathyroid Adenomas-Uncommon Tumours at Unusual Sites: A Cross-sectional Study
Published: August 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/23238.13922
Jagan Chandramohan, Elanthenral Sigamani, Deepak Thomas Abraham, Paul Mazhuvanchary Jacob, Anish Jacob Cherian, Anuradha Chandramohan, Thenmozhi Mani, Marie Therese Manipadam
1. Assistant Professor, Department of Pathology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
2. Associate Professor, Department of Pathology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
3. Professor, Department of Endocrine Surgery, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
4. Professor, Department of Endocrine Surgery, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
5. Associate Professor, Department of Endocrine Surgery, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
6. Professor, Department of Radiodiagnosis, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
7. Senior Demonstrator, Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.
8. Professor, Department of Pathology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Correspondence Address :
Dr. Elanthenral Sigamani,
Fourth Floor, ASHA Building, Christian Medical College Hospital, Vellore-632004, Tamil Nadu, India.
E-mail: sethenral@gmail.com
Abstract
Introduction: Ectopic Intrathyroid Parathyroid Adenomas (ITPAs) are rare and known to pose preoperative and intraoperative diagnostic challenges in localisation, resulting in failure of parathyroid surgery. The common histopathological features of these tumours are not elaborately described in literature.
Aim: To describe the clinico-pathological features of ITPAs, identified among all parathyroid adenomas, diagnosed at a tertiary care hospital.
Materials and Methods: This was a cross-sectional study of all ITPAs diagnosed between January 2012 to December 2019, at Christian Medical College Hospital, Vellore, Tamil Nadu. The gross examination and microscopic findings of ITPAs were reviewed and tabulated. Clinical, radiological and intraoperative findings were compiled to obtain preoperative and intraoperative diagnostic rates.
Results: Among 409 parathyroid adenomas, there were ten ITPAs (2.4%), with eight ectopic inferior (80%) and two ectopic superior parathyroids (20%). Four ITPAs were completely intrathyroid (0.97%). Histopathological features of ITPAs were those of usual parathyroid adenomas. Four patients (40%) had concomitant thyroid disease, including one papillary micro-carcinoma (10%). Correct preoperative diagnostic rate was 40%. Intraoperative misjudgment of location occurred in two patients (20%).
Conclusion: ITPAs are rare and correct preoperative and intraoperative diagnosis may not be always possible. Histopathological evaluation of suspicious intrathyroid nodules is necessary in such instances to correctly diagnose them.
Keywords
Benign, Ectopic, Neoplasm, Parathormone, Thyroid nodules
DOI: 10.7860/JCDR/2020/23238.13922
Date of Submission: Apr 25, 2020
Date of Peer Review: May 13, 2020
Date of Acceptance: Jun 24, 2020
Date of Publishing: Aug 01, 2020
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. No
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Apr 27, 2020
• Manual Googling: Jun 19, 2020
• iThenticate Software: Jul 28, 2020 (9%)
ETYMOLOGY: Author Origin
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