Year :
2020
| Month :
April
| Volume :
14
| Issue :
4
| Page :
BC01 - BC04
Full Version
Lipid Profile and C-Reactive Protein Levels in Healthy, Overweight and Obese Adults: A Hospital-based Observational Study
Published: April 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/43462.13632
Vaneet Kaur, Himanshu Madaan, Meenakshi Puri, Pawan Kumar Kare
1. Associate Professor, Department of Biochemistry, Kalpana Chawla Government Medical College, Karnal, Haryana, India.
2. Professor, Department of Biochemistry, Kalpana Chawla Government Medical College, Karnal, Haryana, India.
3. Assistant Professor, Department of Biochemistry, Kalpana Chawla Government Medical College, Karnal, Haryana, India.
4. Demonstrator, Department of Medical Biochemistry, Gandhi Medical College, Bhopal, Madhya Pradesh, India.
Correspondence Address :
Dr. Pawan Kumar Kare,
Demonstrator, Department of Medical Biochemistry, Gandhi Medical College,
Bhopal, Madhya Pradesh, India.
E-mail: pawankare4@gmail.com
Abstract
Introduction: Numerous biomarkers involved in inflammation have been associated with cardiovascular events, out of which high sensitivity-C-Reactive Protein (hs-CRP), an acute-phase protein, appears to be the most promising. The association between dyslipidaemia and obesity is well established in literature and has been found to be risk factor for Cardiovascular Disease (CVD).
Aim: To study the levels of lipid profile and hs-CRP and also find out the relationship between hs-CRP and Body Mass Index (BMI) in obesity.
Materials and Methods: The present observational study was carried out from June 2018 to August 2018 in Kalpana Chawla Government Medical College, Haryana, India. A total of 100 apparently healthy volunteers, aged 21-60 years were enrolled for this study. The participants were divided on the basis of BMI into three groups; Healthy (normal): 18.5-22.9 kg/m2, overweight: 23-24.9 kg/m2, and obese ≥25 kg/m2. Anthropometric measurements and biochemical investigations were conceded in all the study participants. Lipid profile and hs-CRP levels were estimated on fully automated clinical chemistry analyser. Statistical analysis was conducted using IBM SPSS statistics (version 22.0). A p<0.05 was considered as significant level.
Results: The median levels of HDL were the lowest in the obese group and a statistically significant difference was observed in HDL levels between healthy and obese group (z=3.190, p=0.001) and between overweight and obese group (z=2.760, p=0.006). The median hs-CRP levels were highest in the obese group and statistically significant difference was observed between healthy and overweight group (z=2.009, p=0.044) and between healthy and obese group (z=2.849, p=0.004). A significant positive correlation was observed between BMI and hs-CRP levels (r=0.302, p<0.002). It was further observed that 17 subjects of obese group had hs-CRP levels greater than 3 mg/L as compared to eight of healthy group and nine of overweight group.
Conclusion: The subjects of the obese group are at the highest risk of CVD. Hence, they need to be considered for future development. However, abnormalities of lipid metabolism were not observed in the obese study subjects.
Keywords
Acute phase protein, Body mass index, Cardiovascular disease, Inflammation
DOI: 10.7860/JCDR/2020/43462.13632
Date of Submission: Dec 18, 2019
Date of Peer Review: Feb 01, 2020
Date of Acceptance: Mar 05, 2020
Date of Publishing: Apr 01, 2020
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Dec 21, 2019
• Manual Googling: Feb 20, 2020
• iThenticate Software: Mar 20, 2020 (15%)
ETYMOLOGY: Author Origin
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