Year :
2020
| Month :
February
| Volume :
14
| Issue :
2
| Page :
WD01 - WD03
Full Version
Treatment of Genital Warts with a Combination of Cryotherapy and 5% Imiquimod
Published: February 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/42799.13470
Sneha Deshmukh, Sudhir Singh, Sugat Jawade, Bhushan Madke, Adarsh Lata Singh
1. Junior Resident, Department of Dermatology, JNMC, DMIMS Deemed to be University, Sawangi (Meghe), Wardha, Maharashtra, India.
2. Assistant Professor, Department of Dermatology, JNMC, DMIMS Deemed to be University, Sawangi (Meghe), Wardha, Maharashtra, India.
3. Associate Professor, Department of Dermatology, JNMC, DMIMS Deemed to be University, Sawangi (Meghe), Wardha, Maharashtra, India.
4. Professor and Head, Department of Dermatology, JNMC, DMIMS Deemed to be University, Sawangi (Meghe), Wardha, Maharashtra, India.
5. Professor and Dean Academics, Department of Dermatology, JNMC, DMIMS Deemed to be University, Sawangi (Meghe), Wardha, Maharashtra, India.
Correspondence Address :
Dr. Adarsh Lata Singh,
301, Meghdootam Apartment, Dreamland City, Sawangi (Meghe), Wardha, Maharashtra, India.
E-mail: alsingh1969@gmail.com
Abstract
Genital warts (condyloma acuminata) are benign, proliferative tumours which occur in the genital, anal, perineal and/or perianal areas. These warts are caused by Human Papilloma Virus (HPV). They are double-stranded DNA viruses which replicate in squamous epithelial cells. Many types of HPV has been recognised but 6 and 11 HPV types accounts almost 75-90% of genital warts cases. Many medical and ablative treatment modalities are available like topical podophyllin, imiquimod, cryotherapy, but recurrence is still a problem in many patients. Recently, a concept of combination treatment has been practiced and it was found to be better than monotherapy because of the synergistic effect of both the compounds. There are studies on the use of combination of cryotherapy with topical podophyllin and various other combinations but to achieve complete clearance of genital warts with no recurrence is still a challenge for the dermatologists. Thus, a combination treatment was needed to overcome this problem. So, a thought was given to use a combination of two modalities having different mechanism of action for treating genital warts. We hereby report a case of multiple giant genital warts in an immunocompetent female in whom complete clearance of lesions was achieved by a combination of Cryotherapy and 5% Imiquimod cream within six weeks of treatment.
Keywords
Condyloma acuminata, Human papilloma virus, Topical immunomodulators, Topical therapy
10.7860/JCDR/2020/42799.13470
Date of Submission: Sep 14, 2019
Date of Peer Review: Oct 06, 2019
Date of Acceptance: Nov 27, 2019
Date of Publishing: Feb 01, 2020
AUTHOR DECLARATION:
• Financial or Other Competing Interests: No
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Sep 16, 2019
• Manual Googling: Nov 27, 2019
• iThenticate Software: Jan 09, 2020 (18%)
ETYMOLOGY: Author Origin
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