Autoimmune Hepatitis – Primary Biliary Cirrhosis Overlap Syndrome
Published: July 1, 2017 | DOI: https://doi.org/10.7860/JCDR/2017/25193.10242
Indira Bairy, Anupam Berwal, Shubha Seshadri
1. Professor, Department of Microbiology, Melaka-Manipal Medical College, Manipal University, Manipal, Karnataka, India.
2. Assistant Professor, Department of Microbiology, Melaka-Manipal Medical College, Manipal University, Manipal, Karnataka, India.
3. Professor, Department of Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
Correspondence Address :
Dr. Indira Bairy,
Professor, Department of Microbiology, Melaka-Manipal Medical College,
Manipal University, Manipal-576104, Karnataka, India.
E-mail: indira.bairy@manipal.edu
Abstract
Autoimmune Hepatitis (AIH) and Primary Biliary Cirrhosis (PBC) are important immune mediated liver diseases. They are usually differentiated based on clinical, biochemical, serological, and histological parameters. The presence of autoantibodies, clinical, and serological findings can sometimes occur in different combinations leading to overlap syndromes, which is rare. Early recognition of such overlap syndromes is clinically significant from treatment point of view. Here, we report a case of AIH-PBC overlap syndrome with a brief review of literature on overlap syndromes.
Keywords
Antinuclear antibodies, Antimitochondrial antibodies, Immunofluorescence, Primary sclerosing cholangitis