Aquagenic Wrinkling of Palms: A Case Report
Published: April 1, 2026 | DOI: https://doi.org/10.7860/JCDR/2026/78661.22928
G Sukanya, S Gayathri, C Geo Danny, M Ilanjiyan
1. Professor, Department of Dermatology, Venereology, and Leprology (DVL), Sree Balaji Medical College, Chennai, Tamil Nadu, India.
2. Senior Resident, Department of Dermatology, Venereology, and Leprology (DVL), Sree Balaji Medical College, Chennai, Tamil Nadu, India.
3. Associate Professor, Department of Dermatology, Venereology, and Leprology (DVL), Sree Balaji Medical College, Chennai, Tamil Nadu, India.
4. Junior Resident, Department of Dermatology, Venereology, and Leprology (DVL), Sree Balaji Medical College, Chennai, Tamil Nadu, India.
Correspondence Address :
C Geo Danny,
No. 7, Works Road, Chromepet, Chennai-600044, Tamil Nadu, India.
E-mail: geodanny43@gmail.com
Abstract
Aquagenic wrinkling of the palms is a rare skin condition characterised by rapid wrinkling of the palms after water exposure, occurring within 2-4 minutes, compared to the normal physiological response which takes about 11 minutes. This condition predominantly affects young adult females and involves the eccrine secretory coil and acrosyringium. Cystic fibrosis-associated forms, drug-induced cases, and idiopathic forms have been described. Initial assessment of aquagenic wrinkling of the palms can be performed in a primary care setting. A comprehensive medical history and physical examination should be conducted, with additional investigations as required based on the patient’s presentation. The present case report presents a case of a 23-year-old male with aquagenic wrinkling of the palms, demonstrating wrinkling of the skin within two minutes of water immersion without any underlying systemic condition or drug-induced factors.
Keywords
Acrosyringium, Aquaporin, Cystic fibrosis, Keratoderma, Maceration