Year :
2016
| Month :
August
| Volume :
10
| Issue :
8
| Page :
BC06 - BC08
Full Version
Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus
Published: August 1, 2016 | DOI: https://doi.org/10.7860/JCDR/2016/20156.8257
Niranjan Gopal, Reeta Rajagambeeram, Shruthi Venkatkumar, Mohana Valli Vijayan, Sathish babu Murugaiyan, Shyam Prakash Gopal, Sathiya Ramsamy, Velayutharaj Alwar
1. Associate Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India.
2. Assistant Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India.
3. Student, Indira Gandhi Institute of Dental Sciences (IGIDS), SBV (NAAC ‘A’ Grade), Pillaiyarkuppam, Pondicherry, India.
4. Tutor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India.
5. Assistant Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India.
6. Student, M Pharm in Pharmacology, Mother Theresa Post Graduate and Research Institute of Health sciences, Indira Nagar, Gorimedu, Puducherry, India.
7. Tutor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India.
8. Assistant Professor, Department of Biochemistry, Chennai Medical College, Hospital & Research Centre, Trichy- Tamil Na
Correspondence Address :
Dr. Niranjan Gopal,
Associate Professor, Department of Biochemistry, MGMC & RI, SBV, Pillaiyarkuppam, Puducherry-607 403, India.
E-mail: gopal.niranjan@gmail.com
Abstract
Introduction: The monitoring of glycaemic status in patients with T2DM is mainly through blood tests (Fasting plasma glucose and HbA1c), which are invasive and involves painful pricks. This leads to poor patient compliance and soon could lead to various micro and macro vascular complications, which hamper the quality of life. There are no sensitive and specific markers to predict these complications at the earliest. Sialochemistry has recently gained attention for monitoring chronic diseases. Osteopontin is a phospho-glycoprotein molecule, elevated in many inflammatory conditions.
Aim: The aim of the study was to evaluate the role of serum and salivary osteopontin in Type 2 Diabetes mellitus (T2DM).
Materials and Methods: In this case-control study, we recruited 33 cases of T2DM and 31 age and gender matched healthy controls. Body Mass Index (BMI), Waist/Hip Ratio (WHR), Waist Circumference (WC) and blood pressure was recorded. Fasting Plasma Glucose (FPG), salivary glucose, HbA1c, microalbuminuria, systolic BP, serum and salivary osteopontin levels were estimated.
Results: FPG, salivary glucose, HbA1c, microalbuminuria, systolic BP, BMI, waist / hip ratio serum and salivary osteopontin levels were significantly high in T2DM cases compared to control subjects. Serum and salivary osteopontin levels were significantly correlated with HbA1c and microalbuminuria in T2DM cases.
Conclusion: Serum and salivary osteopontin levels are significantly elevated in subjects with T2DM and are associated with glycaemic control and microalbuminuria.
Keywords
Diabetic nephropathy, Fasting Plasma Glucose, HbA1c
DOI: 10.7860/JCDR/2016/20156.8257
Date of Submission: Mar 14, 2016
Date of Peer Review: May 09, 2016
Date of Acceptance: Jun 09, 2016
Date of Publishing: Aug 01, 2016
Financial OR OTHER COMPETING INTERESTS: None.
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