Year :
2013
| Month :
August
| Volume :
7
| Issue :
8
| Page :
1722 - 1724
Full Version
Holoprosencephaly with Multiple Anomalies of The Craniofacial
Bones-An Autopsy Report
Published: August 1, 2013 | DOI: https://doi.org/10.7860/JCDR/2013/.3268
E. Aruna, V. Kalyan Chakravarthy, D. Naveen Chandar Rao, D. Ranga Rao
1. Assistant Professor, Department of Pathology, Dr. P.S.I.M.S & R.F, China Avutapalli, Andhra Pradesh, India.
2. Professor, Department of Pathology, Dr. P.S.I.M.S & R.F, China Avutapalli, Andhra Pradesh, India.
3. Professor, Department of Pathology, Dr. P.S.I.M.S & R.F, China Avutapalli, Andhra Pradesh, India.
4. Professor, Department of Pathology, Dr. P.S.I.M.S & R.F, China Avutapalli, Andhra Pradesh, India.
Correspondence Address :
Dr. E. Aruna,
Assistant Professor, Department of Pathology,
Dr. P.S.I.M.S. & R.F., Chinnoutpalli, Gannavarum (mandal), Krishna (dist), Andhra Pradesh, India.
Phone: 09849241334, E-mail: drearuna@gmail.com
Abstract
Holoprosencephaly (HPE), a disorder which results from a failure of cleavage or the incomplete differentiation of the forebrain structures at various levels or to various degrees, is related to hereditary factors, chromosomal anomalies, cytogenetic abnormalities, and environmental teratogenic factors. We are reporting a case of a multiparous woman who was G3,P3,L2, who delivered a full term foetus with holoprosencephaly and multiple craniofacial anomalies. An autopsy was conducted. Multiple anomalies of the craniofacial bones, which include hypoplasia and synostosis of the frontal bone, anophthalmia, absence of the anterior cranial fossa, hypoplasia of the maxillae, an absent antrum, cleft palate, a central hare lip and arrhinia which includes absence of the nostrils and hypotelorism of the eye placodes, were noted. This case is being reported for its rarity and the available literature was reviewed in this respect.
Keywords
Holoprocencephaly, Synostosis, Anophthalmia, Craniofacial, Anomalies, Arrhinia, Hypotelorism
Introduction
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DOI: 10.7860/JCDR/2013/5734.3268
Financial OR OTHER COMPETING INTERESTS: None.
Date of Submission: Jan 25, 2013
Date of Peer Review: Mar 06, 2013
Date of Acceptance: Apr 27, 2013
Date of Publishing: Aug 01, 2013
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