Year :
2021
| Month :
March
| Volume :
15
| Issue :
3
| Page :
QC14 - QC18
Full Version
Comparison of Visual Inspection using
Acetic Acid and Liquid Based Cytology
for Cervical Cancer Screening in Rural
Area: A Cross-sectional Study
Published: March 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/47160.14653
Pragya Shree, Nupur Mittal, Vandana Verma
1. Assistant Professor, Department of Obstetrics and Gynaecology, K.D. Medical College, Hospital and Research Center, Mathura, Uttar Pradesh, India.
2. Assistant Professor, Department of Obstetrics and Gynaecology, U.P.U.M.S., Saifai, Etawah, Uttar Pradesh, India.
3. Assistant Professor, Department of Obstetrics and Gynaecology, U.P.U.M.S., Saifai, Etawah, Uttar Pradesh, India.
Correspondence Address :
Pragya Shree,
Flat No. 302, C Block, Faculty Quarters, K.D. Medical College, Hospital and
Research Center, Akbarpur, NH2, Mathura, Uttar Pradesh, India.
E-mail: pragyataashi@gmail.com
Abstract
Introduction: Cervical cancer is the primary malignancy in Indian women. The most significant method for untimely diagnosis of cancer cervix is cytology screening, but it is not possible to launch nationwide cytology screening programme of cervical cancer. So, this has lead to the development of low cost technology e.g., visual inspection of the cervix after application of acetic acid.
Aim: To compare Visual Inspection using Acetic Acid (VIA) and Liquid Based Cytology (LBC) in evaluation of abnormal cervical lesions.
Materials and Methods: This was a cross-sectional study conducted on 1600 women who fulfill selection criteria. Patients attending Gynaecology Outpatient Department (OPD) with the following signs and symptoms like vaginal discharge, abnormal uterine bleeding, lowback pain, contact bleeding, and lower abdominal pain were included. After taking informed consent, the participant was subjected to detailed history, physical examination, LBC, VIA and Colposcopy followed by biopsy (if required). The sensitivity and specificity of each test are determined and compared. Data entry and analysis were done using SPSS Inc., version 11.0.
Results: In present study, VIA was more sensitive (92.06%) than the LBC (68.25%) for the detection of dysplasia. However, the specificities of VIA (56.76%) and LBC (54.05%) had not much difference. Positive Pedictive Value (PPV) of VIA was 78.38% and Negative Predictive Value (NPV) of VIA was 80.77% while PPV of LBC was 71.67% and NPV of LBC was 50%. The accuracy of VIA (79%) is higher than LBC (63%).
Conclusion: The VIA is more sensitive screening modality than LBC. The accuracy of VIA is higher than LBC in detecting premalignant lesion which makes it a suitable and valuable alternative screening method to cytology in poor resource setting.
Keywords
Abnormal cervical lesions, Gynaecology pathology, Gynaecology cancers
DOI: 10.7860/JCDR/2021/47160.14653
Date of Submission: Oct 15, 2020
Date of Peer Review: Nov 09, 2020
Date of Acceptance: Jan 19, 2021
Date of Publishing: Mar 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Oct 15, 2020
• Manual Googling: Jan 08, 2021
• iThenticate Software: Jan 21, 2021 (12%)
ETYMOLOGY: Author Origin
|