Year :
2021
| Month :
January
| Volume :
15
| Issue :
1
| Page :
TR01 - TR03
Full Version
CT Imaging in Gastrointestinal Stromal Tumour: A Case Series
Published: January 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/45995.14413
Arjun H Kamath, Satish Danappa Patil, Shivanand V Patil, Ravi Kumar
1. Junior Resident, Department of Radiodiagnosis, Shri B M Patil Medical College, BLDE University, Vijayapura, Karnataka, India.
2. Associate Professor, Department of Radiodiagnosis, Shri B M Patil Medical College, BLDE University, Vijayapura, Karnataka, India.
3. Associate Professor, Department of Radiodiagnosis, Shri B M Patil Medical College, BLDE University, Vijayapura, Karnataka, India.
4. Assistant Professor, Department of Radiodiagnosis, Shri B M Patil Medical College, BLDE University, Vijayapura, Karnataka, India.
Correspondence Address :
Arjun H Kamath,
Room No- A06, NRI Hostel, Bangaramma Sajjan Campus, BLDE Hospital,
Vijayapura, Karnataka, India.
E-mail: arjunleo21@gmail.com
Abstract
Gastrointestinal Stromal Tumours (GISTs) being most common non-epithelial tumours comprise a bunch of non-epithelial smooth muscle, mesenchymal alimentary tract tumours, appearing from the interstitial cells of Cajal of varying malignancy which specify KIT protein-CD117, a stem cell factor receptor. The mutations seen in GIST’s are most common in the proto-oncogene c-KIT; seen only in GIST. This gene is not seen in the other mesenchyamal tumours. Here, the mutated c-KIT helps in the growth and survival of this tumour by activation of the KIT receptor tyrosine kinase. The incident of GISTs is increasing in recognition and the increased rate of survival has made imaging seemingly important, not only for diagnosis, but also for monitoring the effects of treatment and detecting progression of the tumour. The clinical symtoms in this case series include pain abdomen, nausea, vomiting and constipation. Some cases can present as abdominal distension. The investigation of choice for these spectrum of diseases is currently Computed Tomography (CT), however many imaging techniques, such as Positron Emission Tomography (PET), fluorine 18 Fluorode-Oxyglucose (FDG), Magnetic Resonance (MR) imaging, and Ultrasonography (US) can also be used. This article describes the typical imaging findings of GISTs at initial presentation. Many cases present late and at a stage where surgery will not be of much use. However, Imatinib has showed a drastic response in prognosis and helps increasing the survival changes leading a normal life. This study helps us in identifying the pattern of the lesion and its enhancement patterns leading to early detection, thus aiding the surgeon or the oncologist to plan for treatment.
Keywords
Alimentary tract tumours, Interstitial cells of cajal, Non-epithelial tumours, Receptor tyrosine kinase
DOI: 10.7860/JCDR/2021/45995.14413
Date of Submission: Jul 20, 2020
Date of Peer Review: Sep 29, 2020
Date of Acceptance: Nov 11, 2020
Date of Publishing: Jan 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Jul 26, 2020
• Manual Googling: Nov 05, 2020
• iThenticate Software: Dec 19, 2020 (13%)
Etymology: Author Origin
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