Year :
2020
| Month :
December
| Volume :
14
| Issue :
12
| Page :
OE01 - OE06
Full Version
SARS-Coronavirus Disease-19 and
Comorbidities: A Systematic Review
Published: December 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/45988.14373
Mythri Shankar, KR Nishanth
1. Assistant Professor, Department of Nephrology, Institute of Nephro-Urology, Bengaluru, Karnataka, India.
2. Associate Professor, Department of Cardiology, SJIC, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India.
Correspondence Address :
Mythri Shankar,
926, 22nd Cross, 5th Main, Sector 7, HSR Layout, Bengaluru-560102, Karnataka, India.
E-mail: mythri.nish@gmail.com
Abstract
Introduction: Coronavirus-19 (COVID-19) pandemic is evolving rapidly worldwide. It has led to a worldwide research to identify the people who are at more risk for developing the infection, increasing severity and mortality.
Aim: The aim of this systematic review was to evaluate the risk of some of the common and major comorbidities on the outcome of the disease.
Materials and Methods: A literature search was conducted using EMBASE, PUBMED, Web of science, SCOPUS and Cochrane database. Medical Subject Headings (MeSH) used were "COVID-19" or "SARS CoV 2" or "Coronavirus disease 19" and "Comorbidities" or "Risk factors". Individual risk factors were also used as keywords such as "Diabetes", Hypertension", "Obesity", "Chronic kidney disease", "Elderly", "Cardiovascular disease", "Lung disorders" and "Malignancy". Two researchers conducted the search independently.
Results: After extensive search, 57 articles were shortlisted for complete review. It was found that patients with comorbidities had more severe disease than those without comorbidities. Patients with more number of comorbidities had more severe disease than patients with single comorbidity. Initial reports suggested that elderly were at more risk than the younger population. The most common comorbidity was hypertension followed by diabetes and obesity.
Conclusion: A meticulous triage of patients should be carried out after acquiring proper medical history because this will help to identify patients who are at an increased risk of poor outcome of the infection. Also, they should be given more aggressive treatment upon diagnosis of infection.
Keywords
Diabetes, Hypertension, Kidney disease, Obesity, Pre-existing condition, Risk factors
10.7860/JCDR/2020/45988.14373
Date of Submission: Jul 19, 2020
Date of Peer Review: Sep 17, 2020
Date of Acceptance: Oct 13, 2020
Date of Publishing: Dec 15, 2020
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? NA
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Jul 25, 2020
• Manual Googling: Oct 10, 2020
• iThenticate Software: Dec 14, 2020 (9%)
ETYMOLOGY: Author Origin
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