Year :
2020
| Month :
March
| Volume :
14
| Issue :
3
| Page :
QC01 - QC04
Full Version
Diagnostic Value of Cell Block Method in Ascites Fluid of Ovarian Cancer
Published: March 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/43227.13582
Hiroko Takanashi, Kuniko Suzuki, Akari Nakajima, Ryosuke Saito, Noriko Yamaguchi, Ryusuke Kaya, Keiji Morimoto, Seiji Isonishi
1. Department of Obstetrics and Gynaecology, The Jikei University School of Medicine, Minato-Ku, Tokyo, Japan.
2. Department of Pathology, Jikei Daisan Hospital, Izumi-Honchou, Komae-Shi, Japan.
3. Department of Obstetrics and Gynaecology, The Jikei University School of Medicine, Minato-Ku, Tokyo, Japan.
4. Department of Obstetrics and Gynaecology, The Jikei University School of Medicine, Minato-Ku, Tokyo, Japan.
5. Department of Obstetrics and Gynaecology, The Jikei University School of Medicine, Minato-Ku, Tokyo, Japan.
6. Department of Obstetrics and Gynaecology, The Jikei University School of Medicine, Minato-Ku, Tokyo, Japan.
7. Department of Obstetrics and Gynaecology, The Jikei University School of Medicine, Minato-Ku, Tokyo, Japan.
8. Department of Obstetrics and Gynaecology, The Jikei University School of Medicine, Minato-Ku, Tokyo, Japan.
Correspondence Address :
Dr. Seiji Isonishi,
Department of Obstetrics and Gynaecology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105, Japan.
E-mail: isonishi@jikei.ac.jp
Abstract
Introduction: The traditional studies documented that peritoneal washing cytology in ovarian tumour could detect a subclinical intraperitoneal extension effectively though, they didn’t mention the detailed methodological technique for it. In conventional Cytological Smears (CS), identification of malignant cells has occasionally posed a diagnostic problem, whereas there are some studies corroborating that undetermined malignancies on CS showed conclusive diagnosis with the aid of Cellblock (CB) preparation.
Aim: To assess and compare the accuracy of CB method in the cytological diagnosis of ascites in ovarian cancer with CS.
Materials and Methods: All ovarian cancer specimens for cytopathology consisting of both CS and CB over a 4-year period were reviewed and analysed. The available specimens from 64 cases were compared on sensitivity and yield for malignancy by histologic type.
Results: The overall sensitivity of CS (91%) was almost the same as CB (95%). However, the yield for malignancy could be improved by 6.3% (4/64) when CB were utilised together. The same trend is noted on high grade serous (100% vs 100%; N=27) and clear cell carcinoma (100% vs 92%; N=17) though no improvement on definitive cytologic conclusion for malignancy was observed. Whereas, in endometrioid carcinoma (N=11), the sensitivity of CS (20%) was remarkably inferior to CB (80%) and the yield for malignancy on CS alone (8.2%; 1/11) was significantly improved to 45.5% (5/11) (p=0.048) when CB was combined with CS. More importantly, all four cases exhibiting negative CS with positive CB showed endometrioid carcinoma with endometriosis comorbidity.
Conclusion: These findings strongly suggest that, compared to CS alone, CB technique along with CS provided significant improvement on the yield for malignancy specifically in endometrioid carcinoma.
Keywords
Endometrioid carcinoma, Endometriosis, False negative, Sensitivity, Staging
DOI: 10.7860/JCDR/2020/43227.13582
Date of Submission: Nov 16, 2019
Date of Peer Review: Jan 08, 2020
Date of Acceptance: Feb 18, 2020
Date of Publishing: Mar 01, 2020
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Nov 18, 2019
• Manual Googling: Jan 29, 2020
• iThenticate Software: Feb 25, 2020 (9%)
ETYMOLOGY: Author Origin
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