Year :
2019
| Month :
November
| Volume :
13
| Issue :
11
| Page :
BC08 - BC12
Full Version
Changes in Anthropometry and Biochemical Parameters after Six months of Treatment in Newly Diagnosed Schizophrenic Patients: A Prospective Study
Published: November 1, 2019 | DOI: https://doi.org/10.7860/JCDR/2019/42722.13316
Dimpal Rochlani, Afzal Ahmad, Sanjiv K Bansal, Sanjay Lahariya, Maya Malviya
1. PhD Scholar, Department of Biochemistry, SGT Medical College, Hospital and Research Institute, Gurgaon, Haryana, India.
2. Assistant Professor, Department of Biochemistry, G.S. Medical College and Hospital, Pilkhuwa, Hapur, Uttar Pradesh, India.
3. Professor, Department of Biochemistry, SGT Medical College, Hospital and Research Institute, Gurgaon, Haryana, India.
4. Associate Professor, Department of Psychiatry, Gwalior Mansik Arogyashala, Gwalior, Madhya Pradesh, India.
5. Tutor, Department of Biochemistry, G.S. Medical College and Hospital, Pilkhuwa, Hapur, Uttar Pradesh, India.
Correspondence Address :
Dr. Afzal Ahmad,
Assistant Professor, Department of Biochemistry, G.S. Medical College and Hospital, Near Pilkhuwa Railway Station, Pilkhuwa, Hapur-245304, Uttar Pradesh, India.
E-mail: afzal200ml@gmail.com
Abstract
Introduction: In schizophrenia, chemical pathophysiology is not fully understood. Hereditary, environmental free radical-induced damage is the proposed mechanism associated with it. Drug-related complications in schizophrenia due to altered pro-oxidative and antioxidant homeostasis is the major concern for a psychiatrist.
Aim: To evaluate changes in anthropometry and biochemical parameters by antipsychotic drugs and correlation between Serum Uric Acid (SUA) with other parameters before and after third and six months of treatment, in newly diagnosed schizophrenic patients.
Materials and Methods: In this prospective, observational study based on ICD-10 criteria, 107 drug-naive schizophrenia patients were screened for weight, height, Body Mass Index (BMI), Waist Circumference (WC) as anthropometric variables, Blood Pressure (BP) and biochemical variables i.e., Fasting Blood Sugar (FBS), Total Cholesterol (TC), Triglyceride (TG), High Density Lipoprotein Cholesterol (HDL-c) and uric acid at the time of diagnosis, then after 3rd and 6th months of treatment. Statistical analysis was performed using paired t-test and Pearson’s correlation coefficient. A p-value <0.05 was considered statistically significant.
Results: Significant (p<0.001) increase in SUA levels (5.17±1.3 mg/dL) were found after six months in respect to three months (4.85±1.5 mg/dL) after and before the start of treatment group (4.37±1.6 mg/dL). Increase in BMI, FBS, TC, TG were more after 6th month (26.3±5.2 kg/m2, 105.6±33 mg/dL, 174.5±49.8 mg/dL, 158.1±77.6 mg/dL respectively) compared to 3rd (24.3±4.5 kg/m2, 100.6±31.1 mg/dL, 160.5±38.3 mg/dL, 137.2±54.6 mg/dL respectively) and beginning (22.7±4.1 kg/m2, 95.5±27 mg/dL, 148.9±37.1 mg/dL, 113.2±42.4 mg/dL respectively) of treatment. Significant decrease in level of HDL-c and negative correlation with SUA were recorded after 6th, 3rd month of treatment and at baseline.
Conclusion: This prospective data provides the importance of serial monitoring of SUA in newly diagnosed schizophrenic, its level >4 mg/dL could be the ‘Red flag’ sign to trigger antioxidant SUA into pro-oxidant. These outcomes also provide a hypothetical basis for use of antioxidant supplementation as novel therapeutic strategies. Such implications could improve the prognosis and prevent future complication in schizophrenic patients.
Keywords
Antioxidants, Antipsychotics drugs, Hyperuricaemia, Oxidative stress, Uric acid
DOI: 10.7860/JCDR/2019/42722.13316
Date of Submission: Aug 27, 2019
Date of Peer Review: Sep 18, 2019
Date of Acceptance: Oct 19, 2019
Date of Publishing: Nov 01, 2019
Author declaration:
• Financial or Other Competing Interests: No
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS: [Jain H et al.]
• Plagiarism X-checker: Aug 28, 2019
• Manual Googling: Oct 18, 2019
• iThenticate Software: Nov 01, 2019 (11%)
Etymology: Author Origin
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