Year :
2019
| Month :
October
| Volume :
13
| Issue :
10
| Page :
OC17 - OC19
Full Version
Association between Serum Leptin Levels in Obesity and Type 2 Diabetes Mellitus
Published: October 1, 2019 | DOI: https://doi.org/10.7860/JCDR/2019/42410.13235
Raviraj Gawali, Arun Bahulikar, Deepak Sadashiv Phalgune, Ajit Tambolkar
1. Senior Resident, Department of Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.
2. Head and Consultant Physician, Department of Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.
3. Consultant, Department of Research, Poona Hospital and Research Centre, Pune, Maharashtra, India.
4. Consultant Physician, Department of Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.
Correspondence Address :
Deepak Sadashiv Phalgune,
18/27, Bharat Kunj-1, Erandawane, Pune-38, Maharashtra, India.
E-mail: dphalgune@gmail.com
Abstract
Introduction: It is hypothesised that leptin, the gene product of the obese gene plays an important role in regulating body weight and has a potential role as a treatment tool for obesity and Type 2 Diabetes Mellitus (T2DM). There is little documentation describing the relationship between serum leptin and the indices of obesity such as Body Mass Index (BMI) and T2DM.
Aim: To determine the relationship of serum leptin levels with BMI and type 2 DM patients.
Materials and Methods: This observational study was conducted in 140 patients with known diagnosis of type 2 DM with and without obesity and non-diabetic patient with BMI ≥25 kg/m2. Patient’s BMI and waist hip ratio were noted. Estimation of fasting serum leptin, fasting serum glucose, serum Total Cholesterol (TC), serum Triglycerides (TG), serum High Density Lipoprotein (HDL) cholesterol, serum Low-Density Lipoprotein (LDL) cholesterol and Very Low Density Lipoprotein (VLDL) cholesterol were done. Kruskal Wallis test and Mann-Whitney U test was used to compare median of continuous variables. Correlation analysis was done using Spearman’s correlation technique.
Results: Median serum leptin level was significantly higher in patients who had DM and whose BMI was ≥25 kg/m2. Fasting glucose, TC, LDL cholesterol, and VLDL cholesterol showed statistically significant and positive correlation, whereas HDL-cholesterol showed statistically significant and negative correlation with serum leptin levels.
Conclusion: Serum leptin levels were higher in type 2 DM and obese patients. Fasting glucose, TC, LDL cholesterol, and VLDL cholesterol showed positive correlation, whereas HDL-cholesterol showed negative correlation with serum leptin levels.
Keywords
Correlation, Fasting glucose, Serum triglycerides
DOI: 10.7860/JCDR/2019/42410.13235
Date of Submission: Jul 10, 2019
Date of Peer Review: Aug 02, 2019
Date of Acceptance: Sep 12, 2019
Date of Publishing: Oct 01, 2019
AUTHOR DECLARATION:
• Financial or Other Competing Interests: No
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS: [Jain H et al.]
• Plagiarism X-checker: Jul 11, 2019
• Manual Googling: Sep 10, 2019
• iThenticate Software: Sep 25, 2019 (17%)
Etymology: Author Origin
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