Vitamin D in Treatment-Resistant Carpal Tunnel Syndrome Patients with Hypovitaminosis DCorrespondence Address :
Dr. Sharareh Roshanzamir,
Assistant Professor, Student Research Committee, Department of Physical Medicine and Rehabilitation,
Shiraz University of Medical Sciences, Shiraz, Iran.
Introduction: Vitamin D is significantly effective on health promotion during adulthood. Extraskeletal effects of vitamin D play an important role in tendency to use it in recent years. Vitamin D can be helpful in improving treatment process.
Aim: To study effect of treatment with vitamin D in intractable Carpal Tunnel Syndrome (CTS) patients with hypovitaminosis D referred to the Physical Medicine and Rehabilitation Clinics of Shiraz University of Medical Sciences in 2015.
Materials and Methods: This interventional quasi-experimental study has investigated 50 intractable CTS patients by electrodiagnostic study and physical examinations who have not responded to standard management of CTS for 6 weeks with concomitant hypovitaminosis D (25(OH) vitamin D serum level less than 30 ng/dL) by High Performance Liquid Chromatography (HPLC) method. A dose of 50000 IU vitamin D3 was taken orally per week for 12 weeks. Re-evaluation of patients by electrodiagnostic study was done within one week of taking the last dose. A questionnaire was designed to collect data including age, gender, Body Mass Index (BMI), past medical history, drug history, boston score before and after treatment with vitamin D, serum level of vitamin D before treatment and put data on the Excel 2013 software. Pairwise t-test (a=0.05) and SPSS version 20.0 were used to analyze data.
Results: The mean Boston symptom score before treatment (3.45±0.90) was reduced to (2.04±0.71) after treatment. The mean Boston function score before treatment (3.41±0.85) was reduced to (2.08±0.82) after treatment. Mean Slat values before treatment (4.5±0.57) were reduced to (3.89±0.53) after treatment. Mean Mlat values before treatment (5.03±0.49) were reduced to (4.66±0.44) after treatment. Mean NCV values before treatment (27.02±4.64) were reduced to (32.58±4.54) after treatment. There was a significant difference between Boston scores, Slat, Mlat and NCV values before and after treatment with vitamin D (p-value=0.0001).
Conclusion: It is concluded that treatment with vitamin D improves clinical and electrodiagnostic conditions of treatment-resistant CTS patients with hypovitaminosis D.
Boston scale, Electrodiagnostic study, Peripheral neuropathy
Marzieh Mohtashamkia, Sharareh Roshanzamir, Seyed Mohammad Saghanezhad. VITAMIN D IN TREATMENT-RESISTANT CARPAL TUNNEL SYNDROME PATIENTS WITH HYPOVITAMINOSIS D. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2019 Aug 22 ]; 12:LC23-LC26. Available from
Date of Submission: Dec 29, 2016
Date of Peer Review: Feb 23, 2017
Date of Acceptance: Aug 18, 2017
Date of Publishing: Jul 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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