Association of Serum Vitamin D Levels and Recurrent Wheezing in ChildrenCorrespondence Address :
Dr. Pradeep Debata,
Professor, Department of Paediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital, Delhi-29, India.
Introduction: Wheezing is quite frequently observed in preschool children. There are many risk factors responsible for the development of recurrent wheezing; recently, vitamin D has gained significant interest.
Aim: To study the association of serum vitamin D (25(OH) D) level and recurrent wheeze in children less than three years of age.
Materials and Methods: This was a Case-control study conducted at a tertiary care hospital in New Delhi. Children less than three years with recurrent wheeze along with age matched controls were subjected to analysis of serum vitamin D, calcium, phosphate and alkaline phosphatase levels. The data was analysed to find out an association between the serum levels of vitamin D and recurrent wheezing.
Results: A strong association between the low serum Vitamin D levels and the recurrent wheeze (p=0.001) was found. Also, high levels of serum alkaline phosphatase were seen among the children with recurrent wheezes (677 vs 317 IU/L, p<0.001) and it had an inverse relation with serum vitamin D levels (k-0.688).
Conclusion: Low serum vitamin D level is strongly associated with recurrent wheezing in preschool children.
Alkaline phosphatase, Asthma, Calcium, Phosphate
Afreen Khan, Jogender Yadav, Pradeep Debata, Jagannath Mohapa Apatra, Bhaskar Kabi. ASSOCIATION OF SERUM VITAMIN D LEVELS AND RECURRENT WHEEZING IN CHILDREN. Journal of Clinical and Diagnostic Research [serial online] 2018 October [cited: 2019 Aug 19 ]; 12:SC06-SC09. Available from
Date of Submission: May 01, 2018
Date of Peer Review: Jul 13, 2018
Date of Acceptance: Jul 20, 2018
Date of Publishing: Oct 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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