Nasolabial Extraosseous Benign CD68+ Giant Cell Neoplasm with Low Malignant PotentialCorrespondence Address :
Dr. Ashok Kumar Kapoor,
B-171, Nirala Nagar, Lucknow-226020, Uttar Pradesh, India.
The present case report highlights the histopathological features of a small nasolabial tumour in a 22-year-old female. The tumour was adequately excised. It consisted of proliferated Mononuclear Spindle (MNS) cells admixed with numerous giant cells. Tumour was located in superficial subcutaneous tissue. Immunohistochemical (IHC) examination showed strong positivity of giant cells for anti-CD68+ antibody, suggesting their origin from Monocyte-macrophage (MØ) cells. Both MNS cells and giant cells showed strong positive staining with anti-vimentin antibody. In addition, MNS cells did not show nuclear atypia and mitoses. It was finally diagnosed as a Giant Cell Tumour of Soft Tissue (GCT-ST). It is a highly cellular neoplasm. Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) expression by MNS cells stimulates osteoclast formation, resorption and osteolysis associated with this tumour. A benign course is expected after complete excision of this tumour.
Mononuclear spindle cells, Spindle cell tumour, Subcutaneous
Ashok Kumar Kapoor, Surbhi Rajauria, Akanksha Singh, Anil Kumar Verma. NASOLABIAL EXTRAOSSEOUS BENIGN CD68+ GIANT CELL NEOPLASM WITH LOW MALIGNANT POTENTIAL. Journal of Clinical and Diagnostic Research [serial online] 2018 June [cited: 2018 Sep 20 ]; 12:ED04-ED05. Available from
Date of Submission: Dec 01, 2017
Date of Peer Review: Feb 19, 2018
Date of Acceptance: Mar 26, 2018
Date of Publishing: Jun 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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