Markers of Oxidative Stress, Inflammation and Endothelial Dysfunction in ESRD Patients with Hepatitis-C Virus Positive on Maintenance HaemodialysisCorrespondence Address :
Dr. P.V.L.N. Srinivasa Rao,
Senior Professor and Head, Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences,
Tirupati-517507, Andhra Pradesh, India.
Introduction: Hepatitis C Virus (HCV) infection is the significant cause of morbidity and mortality in Haemodialysis (HD) patients and kidney transplant recipients. HD technique may contribute to maintaining the inflammatory state in many HD patients. Oxidative stress, inflammation and endothelial dysfunction are common in patients with End-Stage Renal Disease (ESRD).
Aim: To assess the possible relationships between oxidative stress, inflammatory and endothelial dysfunction markers with HCV positive status on maintenance HD.
Materials and Methods: The study enrolled 22 patients with ESRD, seropositive for HCV; 22 patients with ESRD, seronegative for HCV on maintenance HD and 19 healthy subjects as controls. In the present study, high sensitivity C-reactive protein (hs-CRP) was estimated by immunoturbidimetry method, Homocysteine (Hcy) was estimated by enzymatic recycling method, Malondialdehyde (MDA), Ferric Reducing Ability of Plasma (FRAP) and Nitric oxide (NO) were estimated by spectrophotometric method and Carotid Intima Media Thickness (CIMT) was estimated by Carotid Ultrasonography.
Results: There is statistically significant increase in serum MDA, Hcy, hs-CRP, CIMT levels and statistically significant decrease in serum NO and FRAP levels in HCV positive and HCV negative groups when compared to controls. Correlation analysis of CIMT with other markers in the study showed statistically significant negative correlations among CIMT with FRAP and NO and statistically significant positive correlations among CIMT with hs-CRP and Hcy but no association with MDA.
Conclusion: Oxidative stress, inflammation, and endothelial dysfunction might be associated with HCV infection in ESRD patients on maintenance HD.
Carotid intima media thickness, Malondialdehyde, Nitric oxide, Seronegative, Seropositive
Krishna Kishore Chennu, Niimmanapalli Harini Devi, PVLN Srinivasa Rao, AY Lakshmi, Vishnubotla Siva Kumar. MARKERS OF OXIDATIVE STRESS, INFLAMMATION AND ENDOTHELIAL DYSFUNCTION IN ESRD PATIENTS WITH HEPATITIS-C VIRUS POSITIVE ON MAINTENANCE HAEMODIALYSIS. Journal of Clinical and Diagnostic Research [serial online] 2018 June [cited: 2018 Oct 18 ]; 12:BC17-BC20. Available from
Date of Submission: Jul 15, 2017
Date of Peer Review: Aug 29, 2017
Date of Acceptance: Nov 22, 2017
Date of Publishing: Jun 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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