Molecular Characterization of Clear Cell Lesions of Head and NeckCorrespondence Address :
Dr. Anshi Jain,
Senior Lecturer, Department of Oral and Maxillofacial Pathology,
I.T.S. Centre for Dental Studies and Research, Murad Nagar, Ghaziabad, Uttar Pradesh-201206, India.
The salivary glands, oral mucosa and jaws constitute a group of lesions which are heterogeneous in nature and are odontogenic, salivary or metastatic in origin. This group of tumours is termed as Clear Cell Tumours. Fixation artifacts are one of the most important reasons for the cell to appear clear but clearing of cells may also result from cytoplasmic accumulation of water, presence of glycogen within the cell, intermediate filaments, immature zymogen granules, or a paucity of cellular organelles. Clear cell Odontogenic neoplasms predominantly include odontogenic carcinoma, ameloblastoma and calcifying epithelial odontogenic tumour. Clear cell tumours of salivary gland origin are almost invariably malignant in nature but they do include two benign lesions. Very frequently, surgical pathologist encounters clear cells in many malignant neoplasms, the nature and sources of which are undetermined on the basis of conventional histopathology. This review will selectively discuss the clinicopathological features of neoplasms which at times may pose a diagnostic challenge and dilemma due to clear cell changes.
Artifact, Fixation, Metastatic, Odontogenic, Salivary
Anshi Jain, Devi Charan Shetty, Saurabh Juneja, Nidhi Narwal. MOLECULAR CHARACTERIZATION OF CLEAR CELL LESIONS OF HEAD AND NECK. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Oct 23 ]; 10:ZE18-ZE23. Available from
Date of Submission: Apr 13, 2015
Date of Peer Review: Jul 01, 2015
Date of Acceptance: Dec 11, 2015
Date of Publishing: May 01, 2016
Financial OR OTHER COMPETING INTERESTS: None.
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