Evaluation of Risk Factors Associated with First Episode Febrile SeizureCorrespondence Address :
Dr. Lesa Dawman,
Room no-61, Girls Hostel no-9, AIIMS, New Delhi-110029, India.
Introduction: Febrile seizure (FS) is the single most common type of seizure seen in children between 6 months to 5 years of age. The purpose of our study was to identify the risk factors associated with the first episode of febrile seizures, which would help in the better management and preventive measures in children at risk for FS episodes.
Aim: To evaluate the risk factors associated with the first episode of febrile seizures in Indian children.
Materials and Methods: This was a hospital based, case control study. The purpose of this study was to identify the risk factors associated with the first FS episode in children. Seventy (70) children between age 6 months to 5 years with their first episode of FS were compared with 70 children with fever but without seizures based on various risk factors.
Results: The mean age was 24.90±16.11 months in cases and 26.34±16.93 months in controls. Male: female ratio was 2:1. A positive family history was found in 31.4% of first degree and 11.4% in second degree relatives. Mean maximum temperature was 102.06±1.1ºF and URI (upper respiratory infection) was most common cause of fever. Antenatal complication was significantly higher in the case group. RBC (Red Blood Cells) indices like lower mean haemoglobin, MCV (Mean Corpuscular Volume), MCH (Mean Corpuscular Haemoglobin concentration) and higher RDW (Red Cell Distribution Width) values were seen in patients. Serum sodium, Serum calcium and random blood sugar values of the cases were significantly lower than those of controls (p<0.05).
Conclusion: Our study shows that male gender, family history of febrile seizures, peak body temperature, underlying cause of fever, antenatal complications, low serum calcium, sodium, blood sugar and microcytic hypochromic anaemia are the risk factors associated with the occurrence of first episode of febrile seizure and, thus, preventive measures in removing these risk factors could lead to a decrease in incidence of FS.
Anaemia, Children, Family history, Upper respiratory infection
Indar Kumar Sharawat, Jitender Singh, Lesa Dawman, Amitabh Singh. EVALUATION OF RISK FACTORS
ASSOCIATED WITH FIRST
EPISODE FEBRILE SEIZURE. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Oct 23 ]; 10:SC10-SC13. Available from
Date of Submission: Dec 30, 2015
Date of Peer Review: Feb 02, 2016
Date of Acceptance: Feb 23, 2016
Date of Publishing: May 01, 2016
Financial OR OTHER COMPETING INTERESTS: None.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2016: 132.37
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)