A Study on Spectrum of Hepatobiliary Dysfunctions and Pattern of Liver Involvement in Dengue InfectionCorrespondence Address :
Dr. Dhrubajyoti Bandyopadhyay,
Senior Resident, Department of Accident and Emergency, Lady Hardinge Medical College, New Delhi, India.
Introduction: The most common arthropod-borne viral (arboviral) disease in humans is dengue. It is transmitted by female Aedes mosquitoes. These mosquitoes are widely distributed in subtropical and tropical areas of the world. Study of dengue infection and its complications are scarce from countries like India.
Aim: In this prospective observational cross-sectional study, we intended to assess the frequency and degree of hepatobiliary dysfunction in adult patients with dengue infection presenting to a tertiary-care medical facility.
Materials and Methods: The details of all patients with serologically proved dengue fever admitted to a tertiary care hospital in eastern India from July 2014 to June 2015 were prospectively reviewed. We collected data including routine blood count, Liver Function Test (LFT), Prothrombin Time (PT), Activated Partial Prothrombin Time (APTT), abdominal ultrasonography from 110 patients.
Results: The maximum number of cases were seen in the age group between 46 years and 61 years and of all cases 55.5% were male and 44.5% were female. Pain abdomen and vomiting were the commonest presenting complaints next to fever which was present in all the cases. Elevated liver enzymes, abnormal values of PT and APTT, thrombocytopenia were observed more commonly in Dengue Shock Syndrome (DSS). Gall bladder wall thickening, thrombocytopenia were seen more commonly in both DSS and Dengue Haemorrhagic Fever (DHF). Plasma leakage such as ascites and pleural effusion on USG were seen more frequently in patients with DHF (76.9% and 73.1%) followed by DSS (72% and 68%) and DF (33.9% and 32.2%).
Conclusion: Hepatobiliary derangement is seen more commonly in severe case of dengue infection. Early recognition of these parameters can also be used as a predictor for assessing the disease severity.
Dengue fever, Dengue haemorrhagic fever, Dengue shock syndrome
Dhrubajyoti Bandyopadhyay, Sayan Chattaraj, Adrija Hajra, Sabyasachi Mukhopadhyay, Vijayan Ganesan. A STUDY ON SPECTRUM OF HEPATOBILIARY DYSFUNCTIONS AND PATTERN OF LIVER INVOLVEMENT IN DENGUE INFECTION. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Oct 20 ]; 10:OC21-OC26. Available from
Date of Submission: Sep 22, 2015
Date of Peer Review: Nov 03, 2015
Date of Acceptance: Feb 22, 2016
Date of Publishing: May 01, 2016
Financial OR OTHER COMPETING INTERESTS: None.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2016: 132.37
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)