Primary Nasopharngeal Yolk Sac Tumor: A Case ReportCorrespondence Address :
Dr. Pavithra Thandavarayan,
BG-6, Krishna Brindhavan Apartment, SNV Garden, Nanjundapuram Road, Coimbatore-641036, Tamil Nadu, India.
Yolk sac tumour also known as primitive endodermal tumour is the most common malignant germ cell tumour (GCT) in the paediatric age group. Most common sites of involvement are ovaries and testes, but rarely can occur in the extragonadal sites. In the head and neck region, yolk sac tumours have been reported in the nasopharynx, sinonasal tract, orbit, ear and parotid gland. Nasopharynx is an uncommon site for yolk sac tumour and very few cases of nasopharngeal pure yolk sac tumour have been reported so far. Yolk sac tumours are highly malignant and have a poor prognosis. This is a case of pure GCT in a three-year-old female child who presented with a rapidly growing nasopharyngeal mass. Histopathological examination followed by immunohistochemistry and serum AFP study clinched the diagnosis of yolk sac tumour. The tumour responded well to chemotherapy as evidenced by decrease in serum AFP levels.
Alpha- fetoprotein, Germ cell tumours, Schiller –Duval bodies
Dhanalakshmi Arumugam, Pavithra Thandavarayan, Lalitha Chidambaram, Sudha Boj, Sumathi Marudasalam. PRIMARY NASOPHARNGEAL YOLK SAC TUMOR: A CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Oct 21 ]; 10:ED06-ED07. Available from
Date of Submission: Oct 31, 2015
Date of Peer Review: Jan 29, 2016
Date of Acceptance: Mar 14, 2016
Date of Publishing: May 01, 2016
Financial OR OTHER COMPETING INTERESTS: None.
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