Synchronous Diffuse Large B-Cell Lymphoma and Malignant Clonal Plasma Cells in Bone Marrow As Primary Presentation: A Diagnostic and Therapeutic ChallengeCorrespondence Address :
Dr. Ritesh Sachdev,
A 803, Plot Number 7A, Navrattan Apartments, Sector 23, Dwarka, New Delhi-110077, India.
E-mail : firstname.lastname@example.org
Coexistence of Diffuse Large B-Cell Lymphoma (DLBCL) with other morphologically and phenotypically distinct lymphoid neoplasm although unusual, has been reported in literature. The most common lymphoid neoplasms associated with DLBCL are Hodgkin’s lymphoma, mantle cell lymphoma and marginal zone lymphoma. However, they have been reported predominantly in the sites other than the bone marrow. Rarely, DLBCL associated with paraproteinemia of IgM type, result of monoclonal plasma cell proliferation, has also been reported in literature. There is either an associated increase in the free light chain levels or disruption in the normal kappa: lambda ratio. However, co-existence of DLBCL with malignant non secretory clonal plasma cells, diagnosed primarily in the bone marrow has not been reported in the literature.
Chemotherapy, Fibrosis, Hodgkin’s lymphoma
Ritesh Sachdev, Shalini Goel, Smeeta Gajendra, Nitin Sood. SYNCHRONOUS DIFFUSE LARGE B-CELL LYMPHOMA AND MALIGNANT CLONAL PLASMA CELLS IN BONE MARROW AS PRIMARY PRESENTATION: A DIAGNOSTIC AND THERAPEUTIC CHALLENGE. Journal of Clinical and Diagnostic Research [serial online] 2015 April [cited: 2019 Aug 18 ]; 9:ED12-ED13. Available from
Date of Submission: Nov 30, 2014
Date of Peer Review: Mar 13, 2015
Date of Acceptance: Mar 18, 2015
Date of Publishing: Apr 01, 2015
Financial OR OTHER COMPETING INTERESTS: None.
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