Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Bengaluru.
On Aug 2018




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Consultant
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Aug 2018




Dr. Rajendra Kumar Ghritlaharey

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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
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Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
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On Jan 2020

Important Notice

Original article / research
Year : 2012 | Month : August | Volume : 6 | Issue : 6 | Page : 1011 - 1013 Full Version

Vitamin D in Ulcerative Colitis: A Cause or an Effect?


Published: August 1, 2012 | DOI: https://doi.org/10.7860/JCDR/2012/.2319
Taghi Amiriani, Somaye Barzanoni, Sima Sedighy, Sima Besharat, Fatemeh Nejadi Kelarijani, Hamidreza Joshaghani, Gholamreza Roshandel, Hamide Akbari

1. Gastroenterologist, Assistant Professor, Golestan University of Medical Sciences, Golestan Research Center of Gastroenterology and Hepatology. 2. Medical Doctor, Golestan University of Medical Sciences. 3. Rheumatologist, Assistant professor, Golestan University of Medical Sciences. 4. Researcher, Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences. 5. Medical Doctor, Golestan University of Medical Sciences, Golestan Research Center of Gastroenterology and Hepatology. 6. PhD of Clinical Biochemistry, Associated Professor, Golestan University of Medical Sciences, Golestan Research Center of Gastroenterology and Hepatology. 7. Researcher, Golestan University of Medical Sciences. 8. Internal Medicine Specialist, Golestan University of Medical Sciences.

Correspondence Address :
Dr. Sima Besharat
3rd Floor, Shahid Nabavi polyclinic,
4th Azar Alley, 5-Azar St, Gorgan City,
Golestan province, Iran.
Phone: 0098-171-2240835
E-mail: besharat@goums.ac.ir

Abstract

Background and Aims: Vitamin D deficiency is common among patients with inflammatory bowel disease, even when the disease is in remission. This study was designed to evaluate the serum levels of 25-hydroxy vitamin D [25(OH)-D3] in patients who suffered from ulcerative colitis and the control group in Golestan province in the northeast of Iran.

Methods: In this case-control study, 60 patients with a definite histopathological diagnosis of ulcerative colitis were included. The control group was selected from healthy blood donors. The serum levels of 25(OH)-D3 were measured by the ELISA method (ids- UK). Data were entered into the SPSS-16 software and were analyzed by t-test and Chi-square test.

Results: The mean serum level of vitamin D in the patients was significantly lower as compared to that in the control group (P-value <0.01). The differences in the levels of 25-OH-D3 were statistically significant between the two sexes, in both groups. A normal vitamin D level was seen in all cases with proctitis, in 20% of cases in the rectosigmoiditis group and in no cases in the pan-colitis group. The difference was statistically significant (p-value <0.01).

Conclusions: It can be concluded that the serum levels of vitamin D in the patients with ulcerative colitis are low and that inflammatory bowel disease can be a target for the specific vitamin D therapy.

Keywords

Vitamin D, Inflammatory bowel disease, Ulcerative colitis

Introduction
Inflammatory Bowel Disease (IBD), which includes Crohn’s Disease (CD) and Ulcerative Colitis (UC), is a chronic disease of unknown multi-factorial aetiologies. The course of the disease is unpredictable and the treatment must focus on the induction and maintenance of remission, on preventing complications and on improving and preserving the quality of life (1). Vitamin deficiencies in general and the vitamin D deficiency in particular, have been reported in patients with inflammatory bowel disease, due to chronic diarrhoea, malabsorption of the nutrients, decreased outdoor activities, a short-term high-dose and a long-term low-dose of prednisone therapy; and it could be common even in the remission time of the disease (2),(3),(4),(5).

Vitamin D is an important immune system regulator. As there are only few foods which contain enough vitamin D, they cannot be used as the only sources of this vitamin (6),(7),(8). On the other hand, it has been shown that the active form of vitamin D (1, 25-dihydroxy vitamin D3) could inhibit the development of autoimmune diseases, including Inflammatory Bowel Disease (IBD) and increase bone mineralization when it is administered to experimental animals and human subjects (6),(9). So, it has not been clearly understood whether the vitamin D deficiency plays a role in causing the inflammation in the first place or whether it is the result of inflammatory bowel disease. This study was designed to evaluate the serum level of 25-hydroxy vitamin D in patients with ulcerative colitis and in a healthy control group in Golestan province, northeast of Iran.

Material and Methods

In this case-control study, 60 patients with ulcerative colitis (N=60) and 60 control healthy persons were included. The exclusion criteria were as followings: a past history of anti-lipid medicines and a history of severe malabsorption diseases, renal disease, and current or past corticosteroid consumption. The cases were selected from IBD patients who were diagnosed not longer than 6 months prior to the study, which were not at the flare-up phase of the disease and they were classified as mild to moderate, to decrease the effect of the inflammation process on the vitamin level. The control group subjects were selected from those healthy blood donors who were referred to “Blood Transfusion Organization” in Gorgan city (N=60), which were age and sex matched. The individuals with gastrointestinal disorders were excluded from the control group. This project was approved by the local ethical committee board, and it was carried out with the adequate understanding and the informed consent of each subject. The serum levels of 25(OH)-D3 were measured by the ELISA method (ids-UK). Data were entered into the SPSS-16 software and analyzed by t-test and Chi-square test. All tests were free of charge for cases and controls and this was a voluntary decision.

Results

The mean serum level of 25(OH)-D3 in the patients (32.03±16.32 ng/dl) was significantly lower as compared to that in the control group (37.78±33.50 ng/dl) (p-value <0.01). The differences in the levels of 25(OH)-D3 were statistically significant between the two sexes in both groups, i.e. it was lower in women. (Table/Fig 1) It was reported that 68% of the men had normal serum levels of 25(OH)-D3, while only 14.3% of the women had normal serumlevels of 25(OH)-D3. The serum levels of 25(OH)-D3 in the patients with ulcerative colitis did not show a significant difference regards to the age groups, ethnicity and Body Mass Index (BMI). All cases in the proctitis group had normal 25(OH)-D3 levels, while only 20% of the cases in the rectosigmoiditis group had normal levels of vitamin D and in the pan-colitis group, there was no case with normal levels of 25(OH)-D3. This difference was statistically significant (p-value <0.01). The serum levels of Vitamin D were found to be significantly decreased when the disease extended into the bowel (Table/Fig 2).

Discussion

In the present study, the ulcerative colitis patients had lower serum levels of 25(OH)-D3 than the subjects in the control group. In other studies, similar results were seen (3),(4),(5). It should be noted that vitamin D is absorbed at the end of the ileum and that ulcerative colitis does not involve the small bowel frequently. By noting the role of vitamin D in the immune system (10) and with regards to the fact that the blood samples of the patients are taken during the very first months of the diagnosis and before the corticosteroids consumption, it could be said that the vitamin D deficiency may contribute to the pathogenesis of inflammatory bowel disease and that it increases the risk of ulcerative colitis. To achieve more accurate results, larger and more precise studies are necessary. The mean levels of serum 25(OH)-D3 were 54.46 ng/dl, 26.51 ng/dl and 18.21 ng/dl in the proctitis, the recto-sygmoiditis and the pancolitis groups, respectively. Maybe the role of the lower levels of vitamin D in the adjustment of the immune system increases the intensity and spread of the bowel inflammation, as has been emphasized by other studies (9),(10), and maybe vitamin D plays a role in the pathogenesis of this disease as has been hypothesized in the present paper.

We found that the serum levels of 25(OH)-D3 were higher in males than in females, both in the cases and in the control group. This may be explained on the basis of the special clothing of the women in our country (they wear dark and thick clothes due to their religious views) and their relative deprivation of the sun light. Based on our results, no significant correlation was found between the serum levels of 25(OH)-D3 and the ethnicity or the Body Mass Index (BMI), which was similar to the findings of others.

Conclusion

And finally, it can be concluded that the serum levels of vitamin D in the patients with ulcerative colitis is low and that this vitamin may play a role in the pathogenesis of this disease; on the other hand, inflammatory bowel disease can be a target for the specific vitamin D therapy.

Authors’ Contributions
Taghi Amiriani, Hamidreza Joshaghani, Sima Sedighy and HamideAkbari supervised the project scientifically, Gholamreza Roshandel analyzed the data, Fatemeh Nejadi Kelarijani and Somaye Barzanoni collected the data and Sima Besharat wrote the paper.

Acknowledgement

The authors thank Dr. Balkhi and his colleagues for performing the lab tests, the Deputy of Research in the Golestan University of Medical Sciences for the financial support of this project and GRCGH for helping in the data gathering. The data were extracted from a doctorate thesis which was submitted to get a doctorate degree.

References

1.
Mittermaier C, Dejaco C, Waldhoer T, Oefferlbauer-Ernst A, Miehsler W, Beier M, et al., The impact of a depressive mood on the relapse in patients with inflammatory bowel disease: a prospective 18-month follow-up study. Psychosom Med 2004; 66(1):79-84.
2.
Ng K, Wolpin BM, Meyerhardt JA, Wu K, Chan AT, Hollis BW, et al.,A prospective study on the predictors of the vitamin D status and on the survival in patients with colorectal cancer. Br J Cancer 2009;101(6):916-23.
3.
Zold E, Szodoray P, Gaal J, Kappelmayer J, Csathy L, Gyimesi E, et al., Vitamin D deficiency in undifferentiated connective tissue disease. Arthritis Res Ther 2008 ;10(5):R123.
4.
Souza HN, Lora FL, Kulak CA, Mañas NC, Amarante HM, Borba VZ . Low levels of 25-hydroxyvitamin D (25OHD) in patients with inflammatory bowel disease and their correlation with the bone mineral density. Arq Bras Endocrinol Metabol 2008; 52(4):684-91.
5.
Vagianos K, Bector S, McConnell J, Bernstein CN. The nutrition assessment of the patients with inflammatory bowel disease. J Parenter Enteral Nutr 2007; 31(4):311-9.
6.
Cantorna MT. Vitamin D and its role in immunology: multiple sclerosis and inflammatory bowel disease. Prog Biophys Mol Biol 2006; 92(1):60-4.
7.
Cantorna MT, Zhu Y. The vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 2004 ; 80 : 1717-20.
8.
Sapone N, Pellicano R, Simondi D, Sguazzini C, Reggiani S, Terzi E, et al., A 2008 panorama on osteoporosis and inflammatory bowel disease. Minerva Med 2008; 99(1):65-71.
9.
Ardizzone S, Cassinotti A, Trabattoni D, Manzionna G, Rainone V, Bevilacqua M, et al., The immunomodulatory effects of 1,25-dihydroxyvitamin D3 on the TH1/TH2 cytokines in inflammatory bowel disease: an in vitro study. Int J Immunopathol Pharmacol 2009; 22(1):63-71.
10.
Brown A, Slatopolsky E. The vitamin D analogs: the therapeutic applications and the mechanisms for their selectivity. Mol Aspects Med 2008; 29(6):433-52.

DOI and Others

ID: JCDR/2012/3872:2319

Date of Submission: Dec 27, 2011
Date of Peer Review: May 25, 2012
Date of Acceptance: Jul 25, 2012
Date of Publishing: Aug 10, 2012

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