Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Dr Archana Dambal

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Dr. Archana Dambal
Department of General Medicine,
Belgaum Institute of Medical Sciences,Belgaum, Karnataka,INDIA,
On 30 Nov 2018




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"The Journal of Clinical and Diagnostic Research (JCDR) has been in operation since almost a decade. It has contributed a huge number of peer reviewed articles, across a spectrum of medical disciplines, to the medical literature.
Its wide based indexing and open access publications attracts many authors as well as readers
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Super Speciality Paediatric Hospital and Post Graduate Teaching Institute, Noida
On Sep 2018




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Believers Church Medical College,
Thiruvalla, Kerala
On Sep 2018




Prof. Somashekhar Nimbalkar

"Over the last few years, we have published our research regularly in Journal of Clinical and Diagnostic Research. Having published in more than 20 high impact journals over the last five years including several high impact ones and reviewing articles for even more journals across my fields of interest, we value our published work in JCDR for their high standards in publishing scientific articles. The ease of submission, the rapid reviews in under a month, the high quality of their reviewers and keen attention to the final process of proofs and publication, ensure that there are no mistakes in the final article. We have been asked clarifications on several occasions and have been happy to provide them and it exemplifies the commitment to quality of the team at JCDR."



Prof. Somashekhar Nimbalkar
Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
Ex-President - National Neonatology Forum Gujarat State Chapter
Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018




Dr. Kalyani R

"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



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Professor and Head
Department of Pathology
Sri Devaraj Urs Medical College
Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
On Sep 2018




Dr. Saumya Navit

"As a peer-reviewed journal, the Journal of Clinical and Diagnostic Research provides an opportunity to researchers, scientists and budding professionals to explore the developments in the field of medicine and dentistry and their varied specialities, thus extending our view on biological diversities of living species in relation to medicine.
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I wish JCDR a great success and I hope that journal will soar higher with the passing time."



Dr Saumya Navit
Professor and Head
Department of Pediatric Dentistry
Saraswati Dental College
Lucknow
On Sep 2018




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Dr. Arunava Biswas
MD, DM (Clinical Pharmacology)
Assistant Professor
Department of Pharmacology
Calcutta National Medical College & Hospital , Kolkata




Dr. C.S. Ramesh Babu
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Best regards,
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Associate Professor of Anatomy,
Muzaffarnagar Medical College,
Muzaffarnagar.
On Aug 2018




Dr. Arundhathi. S
"Journal of Clinical and Diagnostic Research (JCDR) is a reputed peer reviewed journal and is constantly involved in publishing high quality research articles related to medicine. Its been a great pleasure to be associated with this esteemed journal as a reviewer and as an author for a couple of years. The editorial board consists of many dedicated and reputed experts as its members and they are doing an appreciable work in guiding budding researchers. JCDR is doing a commendable job in scientific research by promoting excellent quality research & review articles and case reports & series. The reviewers provide appropriate suggestions that improve the quality of articles. I strongly recommend my fraternity to encourage JCDR by contributing their valuable research work in this widely accepted, user friendly journal. I hope my collaboration with JCDR will continue for a long time".



Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
The journal has a monthly publication and the articles are published quite fast. In time compared to other journals. The on-line first publication is also a great advantage and facility to review one's own articles before going to print. The response to any query and permission if required, is quite fast; this is quite commendable. I have a very good experience about seeking quick permission for quoting a photograph (Fig.) from a JCDR article for my chapter authored in an E book. I never thought it would be so easy. No hassles.
Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011

Important Notice

Case report
Year : 2011 | Month : April | Volume : 5 | Issue : 2 | Page : 361 - 363

Salivary duct carcinoma of the minor salivary glands: A rare case report

RAJINI KANTH M, A RAVI PRAKASH, P SREENIVAS REDDY

G Pulla Reddy Dental College and Hospital, Kurnool, AP, India

Correspondence Address :
Dr Rajini Kanth M, Associate Professor,
G Pulla Reddy Dental College & Hospital, Kurnool,
Andhra pradesh, India
E mail address: dentopathfinder@yahoo.com

Abstract

Salivary duct carcinoma (SDC) is a rare invasive malignancy arising in the ductal epithelium of the salivary glands. These are an uncommon but distinct group of highly malignant salivary gland tumours. These are usually seen in the major salivary glands, especially in the parotid gland. This malignancy was established as a distinct clinicopathological entity and was delineated from ‘’adenocarcinoma (NOS)” in 1991 by the World Health Organization. Salivary duct carcinomas affecting the minor salivary glands have been reported in only 4% of the SDC cases and constitute 2% of all the salivary gland malignant neoplasms. Its biological behaviour is highly aggressive; the metastatic and the tumour-related death rates were 75% and 73%, respectively. In this article, wereport a case of a salivary gland carcinoma which was present in the palate of a 55-yearold male patient.

Keywords

Duct Carcinoma, minor salivary glands

How to cite this article :

RAJINI KANTH M, A RAVI PRAKASH, P SREENIVAS REDDY. SALIVARY DUCT CARCINOMA OF THE MINOR SALIVARY GLANDS: A RARE CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2011 April [cited: 2019 Aug 26 ]; 5:361-363. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2011&month=April&volume=5&issue=2&page=361-363&id=1259

Case Report

A 55-year-old male patient was referred with a complaint of growth in the left upper posterior region of the maxilla for the past 4 months. He was apparently healthy and no abnormalities were detected on extra oral examination. On intra-oral examination, a non tender, dome shaped, ulcerated swelling was seen extending from the upper left second premolar on the buccal side to the first molar region. The lesion was 3 x 3 cm in size, erythematous and with irregular margins. On the lingual side, a hard mass was present since 30 years.(Table/Fig 1) On palpation, the lesion was found to be tender and soft to hard in consistency. No lymph nodes were detected. The orthopantamogram revealed a wide area of bone loss in the upper left molar region.(Table/Fig 2) A provisional diagnosis of peripheral giant cell granuloma and squamous cell carcinoma/ mucoepidermoid carcinoma was given, based on the clinical details. An incisional biopsy was performed under local anaesthesia and the specimen was sent for histopathological evaluation. The histopathological features of the lesion revealed numerous infiltrating islands and cords of neoplastic glandular epithelium in a fibrovascular connective tissue. Most of the neoplastic islands exhibited central “comedonecrosis (Table/Fig 3).. The neoplastic cells were cuboidal to polygonal in shape and exhibited cellular pleomorphism, eosinophilic cytoplasm, nuclear hyperchromtism and prominent nucleoli (Table/Fig 4). Numerous blood vessels and mitoses were present. The lesion was covered by a parakeratinized, stratified squamous surface epithelium. Based on the histopathological features, a diagnosis of salivary duct carcinoma was made.

Discussion

SDC was first described by Kleinsasser in 1968 (1) and was further defined by several authors. It was only recently recognized as a distinct clinic-pathological entity. The origin of the neoplasm from the salivary ducts was initially suggested by its morphological resemblance to mammary duct carcinoma and it was later supported by the identification of preinvasive disease, ductal dysplasia and carcinoma in situ in the intralobular and the extralobular ducts.(2) (3) Salivary ductal carcinoma occurs predominantly in males, with a male to female ratio of 2:1. The ages of these patients ranged from 23-80 years, with more cases being reported in the fifth and sixth decades of life. These are usually seen in the major salivary glands, especially in the parotid gland. (4) Salivary duct carcinoma affecting the minor salivary glands has been reported in only 4% of the SDC cases and constitutes 2% of all the salivary gland malignant neoplasms. Intra-orally, the common sites of occurrence are the palate, followed by the buccal mucosa / vestibule, the upper lip, the maxilla and the mandible. (5) Salivary duct carcinoma, which was recently recognized as a high grade, aggressive malignancy of the major salivary glands, is characterized histologically by a striking resemblance to ductal carcinoma of the breast. The terms, ‘cribriform salivary carcinoma of the excretory duct’ and ‘infiltrating salivary duct carcinoind’ have been recommended for SDC, to distinguish it from other salivary carcinomas, many of which may also be “ductal” in origin.’” However, the designation, ‘salivary duct carcinoma’ has gained acceptance because it is used in the WHO classification of tumours.” The separation of SDC from the category, “adenocarcinoma NOS (not otherwise specified)”, is warranted by its predictably aggressive behaviour. (4) This tumour may arise within a pleomorphic adenoma as a result of the malignant transformation of the ductal epithelial cells. In addition, a multifocal origin from the major excretory ducts surrounding a pleomorphic adenoma was observed in one of the cases. SDC exhibits a wide range of histological appearances. (3) The histopathological features of SDC consist of atypical cuboidal or polygonal cells which are arranged in papillary cribriform and solid growth patterns along with duct like structures. The tumour cells are polygonal in shape, with granular eosinophilic cytoplasm, enlarged hyperchormatic, pleomorphic nuclei and prominent nucleoli. Pseudocyst formation and central comedonecrosis are seen in the neoplastic islands. (‘Comedonecrosis’ means a type of necrosis occurring in the glands, in which there is central luminal inflammation with devitalized cells, which usually occurs in the breast in intraductal carcinoma). Vascular invasion and perineural infiltration have been reported in some cases. Atypical mitotic figures are seen in most of the lesions. Dystrophic calcifications are seen in some cases. The differential diagnosis of SDC (6), (7), spans a range of low-grade and high-grade salivary gland malignant neoplasms, the most common ones of which include papillary cystadenocarcinoma, papillary cystic acinic cell carcinoma, metastatic adenocarcinoma, etc. Lymph node metastases have been reported in 22% of the SDC cases in the minor salivary glands, as compared to 83% in the SDC of the major salivary glands. However, multiple metastases and a high mortality rate of 60-75% are associated with the minor salivary gland SDCs. A recurrence rate of 33-35% has been reported from a study on SDC patients.(8), (9) (10). . The treatment of this lesion involves the radical surgical excision of the lesional tissue and its associated structures, with concomitant neck dissection, followed by post-operative radiation therapy.

References

1.
. Kleinsasser O, Klein ILL Hubner G. Speichelgangcarcinome. Fin den Milchgancarcinomen der Brustdruse analoge Gruppe von Speicheldrusentumoren. Arch Klin Exp Ohren Nasen Kehlkopfheilkd, 1968; 192:100-5.
2.
. Margaret S. Brandwein, Jaishree Jagirdar, Jaygonda Patil, Hugh Biller and Mamoru Kaneko. Salivary Duct Carcinoma (Cribriform Salivary Carcinoma of Excretory Ducts) A Clinicopathologic and Immunohistochemical Study of 12 Cases. Cancer 1990; 65: 2307-2314,
3.
. Ruby Delgado, Frank Vuitch and Jorge Albores-Saavedra, Salivary Duct Carcinoma: Cancer 1993; 721503-12.
4.
. Nalin Kumar S, Ranganathan K, Nathan JA, Saraswathi TR. Salivary duct carcinoma of minor salivary gland. J Oral Maxillofac Pathol 2004; 8:87-90
5.
. Lewis, J. E., McKinney, B. C., Weiland, L. H., Ferreiro, J. A. and Olsen, K. D. Salivary duct carcinoma: Clinicopathologic and immunohistochemical review of 26 cases. Cancer, 1996; 77: 223–230.
6.
. Crawford Anderson, Richard Muller, Robert Piorkowski, David R. Knibbs,Paul Vignoti. lntraductal Carcinoma of Major Salivary Gland. Cancer 1992; 69609-614
7.
. Ken Motoori, Yumiko Iida,Yuichirou Nagai, Seiji Yamamoto, Takuya Ueda Hiroyuki Funatsu Hisao Ito and Okamoto Yoshitaka : MR Imaging of Salivary Duct Carcinoma. American Journal of Neuroradiology 2005;26:1201-1206,
8.
. Jean E. Lewis, Barbara C. McKinney, Louis H. Weiland, Jorge A. Ferreiro M.D, Kerry D. Olsen: Salivary duct carcinoma: Clinicopathologic and immunohistochemical review of 26 cases. Cancer. 1996,Volume 77, Issue 2, pages 223–230, 15
9.
. Cheuk, Wah, Miliauskas, John R, Chan, John K.C. Intraductal Carcinoma of the Oral Cavity: A Case Report and a Reappraisal of the Concept of Pure Ductal Carcinoma in Situ in Salivary Duct Carcinoma: American Journal of Surgical Pathology: 2004 - Volume 28 - Issue 2 - pp 266-270
10.
. Ponniah I, Murali GM, SureshKumar P, Kumaran MG, Shaheen A. Salivary duct carcinoma of the palate. Indian J Dent Res 2005;16:167

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