Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Super Speciality Paediatric Hospital and Post Graduate Teaching Institute, Noida
On Sep 2018




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Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
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Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018




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"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



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Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
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Saraswati Dental College
Lucknow
On Sep 2018




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Calcutta National Medical College & Hospital , Kolkata




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On Aug 2018




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Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
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An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help ones reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

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Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journalsNo manuscriptsNo authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011

Important Notice

Original article / research
Year : 2009 | Month : August | Volume : 3 | Issue : 4 | Page : 1641 - 1646

The Effect Of Dexamethasone On Morbidity Related To Vomiting, Pain and Oral Intake In Children After Tonsillectomy

KHANI A*,JAAFARPOUR M**,KHAJAVIKHAN J***,DYREKVANDMOGADAM A**

*MScin Nursing,** Msc in Midwifery, Nursing & Midwifery faculty, ***Anesthesiologist, Dept. Of Anaesthesiology, Medicine Faculty,ILAM University Of Medical Science,ILAM,IR-(IRAN)

Correspondence Address :
Ali khani, Msc in Nursing,
Dept of Nursing, Nursing & Midwifery faculty,
ILAM University Of Medical Science, ILAM, IR-(IRAN)
E-mail : nimakhani@gmail.com Tel : +989188345385

Abstract

Background and Aim: Morbidity related to postoperative nausea and vomiting, pain, poor oral intake, dehydration and fever is a concern in children undergoing tonsillectomy. The aim of this study was to investigate the effects of preoperative 0.5 mg/kg i.v. dexamethasone on postoperative quality oral intake, vomiting and pain in paediatric patients undergoing tonsillectomy with or without adenoidectomy, during the first 8 hours of the postoperative period.
Material and Methods: This is a quasi-experimental study that was performed at the Ilam Imam Khomeini hospital, IR, during the year 2008-2009. In a randomized, double-blind trial, 66 paediatric patients undergoing tonsillectomy received IV placebo (saline) or 0.5mg/kg IV dexamethasone, after the induction of anaesthesia before surgery. The incidence of vomiting, the time to the first oral intake, the quality of oral intake and the pain score were compared in both groups during the first 8 hours of the postoperative period. Pain was assessed using a five-point ‘‘faces’’ scale (1 = smiling face: no pain, 5 = crying face: highest pain score). The quality of the oral intake was judged as follows: excellent = child requests it, good = child accepts it when offered, fair = child accepts it when coaxed, and poor = child refuses. All collected data were analyzed using the statistical software (SPSS, Ver.11.5), descriptive statistics, Student t test, Mann-Whitney test and the χ2 or Fisher’s exact tests. p < 0.05 was considered significant.
Results: The overall incidence of vomiting was significantly less in the Dexamethasone group as compared to the Saline group (p<0.001). The time of the first oral intake was shorter in the Dexamethasone group as compared to the Saline group (P<0.05). The quality of oral intake was better in the Dexamethasone group than in the Saline group (P<0.001). When compared with placebo, the patients who received preoperative dexamethasone had a significantly less pain score during the first 8 hours postoperatively ( p < 0.05).
Discussion and conclusion: In the paediatric patients undergoing tonsillectomy, preoperative dexamethasone use significantly reduced posttonsillectomy pain, improved oral intake and decreased vomiting without any significant side effects. This report confirms the beneficial effect of IV dexamethasone on postoperative morbidity related to vomiting, pain and oral intake in children after tonsillectomy and is recommended for routine use.

Keywords

Dexamethasone, vomiting, pain, children , tonsillectomy

Introduction
Tonsillectomy with or without adenoidectomy is one of the most frequently performed surgical operations in children and is associated with an incidence of postoperative vomiting ranging between 40% and 73% (1),(2),(3),(4),(5),(6),(7). Morbidity related to postoperative nausea and vomiting (PONV), pain, poor oral intake, dehydration and fever, however, continues to be a concern in children undergoing tonsillectomy in ambulatory setting (2),(7). The delay in postoperative oral fluid intake and also inadequate oral feeding because of the nausea, vomiting and pain prolongs the discharge period, and also increases dehydration risk in the early or late postoperative period. Because of these reasons, it is extremely important in paediatric patients to bring pain, nausea and vomiting under control and also to start oral fluid intake in the earliest postoperative period (7). Sutters et al. (2005) reported that 33% of the children in their sample experienced moderate to- severe nausea on the first evening after the procedure and 25% reported moderate-to-severe vomiting (8).

Splinter reported that each vomiting episode prolonged the hospital stay approximately by 13.2 min (9). In children, postoperative vomiting causes distress and anxiety and may result in dehydration, metabolic disturbances, delayed discharge from the hospital, as well as unplanned hospital admission (4).The incidence of postoperative emesis is more frequent in paediatric patients than in adults (10). Anaesthesiologists and otolaryngologists are seeking methods that will minimize this problem, especially in day care surgical programs (9). Research has consistently reported children’s pain during home recovery from tonsillectomy and adenoidectomy as moderate to severe in nature, and lasting more than 7 days(11),(12),(13),(14). In one study, children described the passage of time and medication as contributors to pain relief (15).

Severe pain in tonsillectomy is reported in 25–50% of children and has traditionally been controlled with morphine, resulting in a high incidence of PONV as compared to other forms of analgesia. Respiratory depression and sedation from morphine may also be hazardous after pharyngeal surgery (3). In one study, children with higher pain intensity ratings also reported less fluid intake, significantly more sleep disturbances and more behavioural changes than children with intensity scores of 0 or 1. The literature provides evidence of the inadequate treatment of postoperative pain after tonsillectomy and adenoidectomy and supports the need for further research (15). In view of these side effects, alternative analgesic strategies have been suggested.

In children undergoing tonsillectomy, dexamethasone and other steroid preparations have been used to minimize tissue injury and oedema and related morbidity such as pain, fever and poor oral intake (2). The antiemetic effect of dexamethasone has been demonstrated in cancer patients receiving chemotherapy and also after gynaecological , laparoscopic and caesarean operations (16),(1),(2),(17). Dexamethasone lacks side effects when used as a single injection and has a low cost and a prolonged biological half-life of 36 to 48 hours. Also, it has combined antiemetic and anti-inflammatory effects that may decrease postoperative oedema and subsequently may improve oral intake after tonsillectomy. However, many reports have questioned the efficacy of dexamethasone as an antiemetic as well as its beneficial effect on the quality of oral intake after tonsillectomy. This controversy may be attributed to the wide range of dosages of dexamethasone as well as the wide variety of anaesthetic techniques used (1).

The effect of dexamethasone in tonsillectomy-associated PONV, pain and oral intake however, is controversial (2). Therefore, the aim of this study was to investigate the effect of 0.5 mg/kg i.v. dexamethasone given before the induction of anaesthesia on quality oral intake and vomiting and pain in paediatric patients undergoing tonsillectomy with or without adenoidectomy during the first 8 hours of the postoperative period.

Material and Methods

This is a quasi-experimental study that was performed at the Ilam Imam Khomeini hospital, IR, during the year 2008-2009. After approval from the institution’s ethical committee and informed consent from the parents, 66 patients who were 4—12 years old, undergoing tonsillectomy with or without adenoidectomy, were enrolled in the study.

The study design was randomized, double-blinded and placebo-controlled. Children who received antiemetics, steroids, antihistaminics, or phychoactive drugs within 24 hours before surgery were excluded from the study. Additionally, children in whom i.v. induction was indicated or steroid administration was contraindicated, and patients with diabetes and mental retardation were not included in the study. Oral intake was stopped 8 hours and clear fluids were stopped 4 hours preoperatively (1),(2),(8).

After establishing standard monitoring, general anaesthesia was induced using halothane and a gas mixture of 50% nitrous oxide and oxygen. Each child received 1 µg/kg of fentanyl before surgery. 0.5 mg/kg of Dexamethasone (maximal dose 8 mg, Dexamethasone group) or an equal volume of saline (control group) was administered as IV in a randomized double-blind fashion after the induction of anaesthesia before surgery. Randomization was guided by a computer-generated number table. Age, weight, surgery time, anaesthesia time, need for requirement opioids in the PACU, incidence of PONV, need for rescue antiemetics and the quality of oral intake were documented for each patient.

The patients were closely observed for their vomiting, pain and for possible agitation status in the post anaesthesia care unit. The incidence of vomiting was recorded by the PACU nurse. The patients who met the criteria (stable vital signs, adequate pain control and absence of vomiting) were transferred to floor after 2 hours.

Pain, vomiting and oral intake were assessed by an independent observer at hourly intervals. Postoperative variables including vomiting, pain and the quality of oral intake were recorded in the ward at the 1, 3, 6 and 8 hrs, postoperatively. Pain was assessed using a five-point ‘‘faces’’ scale (1 = smiling face: no pain, 5 = crying face: highest pain score)(7). After the parents and the nurse caring for the child were informed about the procedure, oral fluids were offered duing the second postoperative hour. The quality of oral intake was judged as follows: excellent = child requests it, good = child accepts it when offered, fair = child accepts it when coaxed, and poor = child refuses (2),(7). Vomiting was defined as the forceful expulsion of liquid gastric contents. Nausea was not recorded because it is difficult to assess in children (9). Vomiting was treated with 0.15 mg/kg metoclopramide IV when it occurred more than twice. Postoperative analgesia was provided with a morphine (50 µg/kg IV) – the routine analgesic treatment in our institution. All collected data were analyzed using the statistical software (SPSS, Ver.11.5), descriptive statistics, Student t test, Mann-Whitney test and the χ2 or Fisher’s exact tests. p < 0.05 was considered significant.

Results

None of the 66 enrolled patients was withdrawn for any reason. Baseline patient characteristics and the duration of surgery and anaesthesia are shown in (Table/Fig 1). Demographic details and the duration of anaesthesia and the operation were not significantly different between the two groups [Table /Fig 1]. The incidence of postoperative vomiting was not significantly different between the two groups before PACU discharge (12.1% in the Dexamethasone group versus 15.1% in the Saline group, P> 0.05). The incidence of late vomiting, as well as the overall incidence of vomiting during both the PACU and the floor stay, was significantly more frequent in the control group (6% versus 36.3%, P < 0.05 for late vomiting and 18.1% versus 51.5%, P < 0.001 for the overall incidence of vomiting). Also, the total antiemetic requirement was lower in the Dexamethasone group (p<0.001) [Table /Fig 2]. The time for the first oral intake was significantly shorter, and the quality of oral intake was significantly better in the Dexamethasone group (P <0.05 and p<0.001, respectively) [Table /Fig 2]. Patients in the dexamethasone group had significantly lower pain after tonsillectomy and the total consumption of the analgesic was lower in this group than in the placebo group (P < 0.05 and p<0.05, respectively) (Table/Fig 2).

Discussion

Discussion and Conclusion
The aim of this study was to investigate the effects of 0.5 mg/kg i.v. dexamethasone given before the induction of anaesthesia on the quality of oral intake, vomiting and pain in paediatric patients undergoing tonsillectomy with or without adenoidectomy during the first 8 hours of the postoperative period. The efficacy of dexamethasone as an antiemetic has been well established in chemotherapy induced nausea and vomiting, but studies of its antiemetic potential in children undergoing tonsillectomy have produced conflicting results (2).

In this present study, the administration of preoperative dexamethasone at a dose of 0.5 mg/kg in patients undergoing tonsillectomy with or without adenoidectomy in the sharp dissection technique was associated with a reduced postoperative pain score, reduced vomiting and an increased quality of oral intake during the hospital stay.

Although some studies failed to show any significant effect of dexamethasone on the incidence of postoperative vomiting, there have been a quite number of randomized, placebo-controlled studies revealing a decrease in vomiting incidence (7). Aouad et al. found that the vomiting incidence in patients undergoing tonsillectomy or adenotonsillectomy and in those who were administered 0.5 mg/kg of dexamethasone preoperatively was 10% and in the placebo group, it was was 30% ( p < 0.05) (1). In a similar study, Elhakim et al. demonstrated that the vomiting incidence was 30% and 56%, respectively in both the groups (p < 0.05) (19).

Volk et al, in a prospective, randomized, double-blind study, observed no differences in postoperative recovery variables such as oral intake, level of activity and analgesic use in children who received a single dose of 10 mg of dexamethasone IV versus placebo, although they did not specifically examine PONV. Catlin and Grimes examined the incidence of vomiting in addition to pain, fever, and oral intake in 25 children (4-12 yrs of age) who received placebo or dexamethasone (8mg) IV before tonsillectomy. The only difference they observed was after returning to a full diet, which was faster after the intake of dexamethasone (1).

In the meta-analysis of eight published studies, Steward et al reported that in patients undergoing tonsillectomy, preoperative dexamethasone decreased the vomiting incidence two times and improved the oral intake of clear fluids and a soft diet within the first 24 hours when compared with the placebo group. On the other hand, when pain scores were compared, these studies failed to show any significant difference because of missing data and differences in the evaluation methods. (20). The antiemetic action of dexamethasone occurs via prostaglandin antagonism and by the release of endorphins and tryptophan depletion. But it is not clear whether dexamethasone shows its effect by a central or peripheral mechanism in this procedure (7). The efficacy of dexamethasone in minimizing late PONV in this study and several other published studies is consistent with its biological half-life of 36-48 hrs.(7),(2). Factors that may influence vomiting include age, surgical procedures, anaesthetic care, postoperative management, and concurrent drugs (9). Unlike the studies that demonstrate the positive effects of dexamethasone on pain in patients undergoing adenotonsillectomy, some published papers could not reach the same results (7). In our study, the pain score in the first 8 hrs of the postoperative period was lower in the dexamethasone group as compared to the control group (p < 0.05). These results may be attributed to the anti-inflammatory effect produced by dexamethasone, which may reduce local oedema and pain (7).

The time for the first oral intake was shorter in the Dexamethasone group as compared to the Saline group. The quality of oral intake was better in the Dexamethasone group as compared to the Saline group. These results may be attributed to the antiinflammatory effect produced by corticosteroids, which may reduce oedema and pain (1). Aouad et al. noted that the first oral intake time in the dexamethasone group was 5.3 hrs and that in the placebo group was 10.9 hrs (p < 0.05), and also oral intake quality was higher at 24 hrs postoperatively in the dexamethasone group (1). Pappas et al. found no significant difference while comparing the pain scores and the quality of oral intake within the first 3 hrs between the two groups postoperatively; however, when examining the 24 hr quality of oral intake, the dexamethasone group showed significant improvement (2). Complications from corticosteroids therapy such as an increased rate of infection, peptic ulceration, and adrenal suppression, are usually related to its long term use. The risks of steroid therapy of 24 hours are negligible (1),(2),(7).

In conclusion, our results showed that the use of dexamethasone 0.5 mg/kg IV up to 8 mg after the induction of anaesthesia in children undergoing tonsillectomy with or without adenoidectomy significantly decreases the incidence of postoperative vomiting, mainly after discharge from the PACU. Also, it improves the quality of oral intake, shortens the time to the first oral intake and decreases the postoperative pain.

Acknowledgement

We thank Miss Raofian of Ilam Imam Khomeini hospital for providing valuable inputs for this study.

References

1.
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