Article in PDF
How to Cite
Citation Manager
Readers' Comments (0)
Audio Visual Article Statistics
Link
to PUBMED
Print this Article
Send to a Friend
Advertisers
Access Statistics Resources
Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."
Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011
Dr. Shankar P.R.
"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."
Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011 Anuradha
Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.
Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020
Dentistry
Full Version
Effect of Treatment of Periodontitis on C-reactive Protein, Tissue Plasminogen Activator and High-serum/Low Density Lipoprotein in Cholesterol: A Pilot Study
Correspondence Address :
Dr. Balwant Rai, Village – Bhangu Distt. Sirsa Post Office – Sahuwala, India. E-mail: drbalwantraissct@rediffmail.com Mobile No : 091-9812185855.
Background: Periodontitis is associated with elevated levels of C-reactive protein (CRP), tissue plasminogen activator (tPA) and low density lipoprotein cholesterol (LDL-C), recently postulated as coronary heart disease or cardiovascular disease risk factor.
Material and Methods: (CRP), (tPA) and (LDL-C) levels were measured in 12 patients (7M:5F) with periodontitis, before and after treatment (scaling and root planning).
Results: Periodontal treatment significantly decreased CRP, t-PA and LDL-C levels in these individuals, and it may thus decrease their CHD risk.
Periodontitis, Biomarker, Scaling, Root Planning
Introduction
Periodontitis is defined as a group of conditions that cause inflammation and destruction of the attachment apparatus of teeth. Epidemiological associations between periodontitis and cardiovascular disease have been reported.(1),(2) This could directly be due to the direct action of periodontal pathogens or their products on endothelial cells via transient bacteraemia, or indirectly due to products of the inflammatory response.3-5 Periodontitis and atherosclerosis have complex aetiologies and genetic and gender predispositions, and may share pathogenic mechanisms as well as common risk factors. Also, increased levels of serum LDL-C, and chronic inflammatory markers CRP and t-PA (a parameter of endothelial function) have been related to increased cardiovascular risk.6-8 Several short term inventory studies have reported that treatment of periodontitis reduces the serum concentrations of inflammatory markers.(9)
Twelve M:F 7:5 (Table/Fig 1)(in age group of 31-40 years), having at least a minimum of seven sites exhibiting 6 mm loss as clinical attachment and the number of teeth in the dentition of at least 20, were studied. Patients were excluded from the study if they were alcoholic or chronic smokers, since they are a predisposing factor for periodontitis.Informed consent was obtained from all the included subjects. None of the patients selected, had any history of chronic inflammatory disease, diabetes, hypertension, or use of steroids or drugs. In all these cases, the peripheral blood was drawn before starting any treatment, one week later after scaling and root planning; and 3 weeks after scaling and root planning for investigation i.e. CRP, LDL-C and t-PA antigen. Plasma was obtained after centrifugation at 1500 g for 10 min, and was stored at –40C until analysis. CRP was analysed by immuno assay (using Mentura, CA, USA). t-PA concentrations were determined by ELISA (Imulgse tPA, Biopool International), and LDL-C was estimated enzymatically. The data was analyzed by SPSS 7.0.
CRP, t-PA and LDL-C levels were elevated in periodontitis. i.e. after treatment, patients fell significantly from T1 to T3 and from T2 to T3 (Table/Fig 2),(p<0.01)
Cumulative evidences support a casual association between periodontal infection and artherolerotic cardiovascular, or its sequelae(10). Earlier evidences from interventional studies suggest that controls of periodontal infections may result in the improved levels of markers of systemic inflammations and measures of endothelial dysfunctions.(11) Plasma levels of CRP as an inflammatory marker have been accepted as systemic markers for risk of cardiovascular disease.9 D'Aiuto et al reported reductions of CRP levels, six months after periodontal therapy.(12) The present study is an exploratory study which showed that high blood levels of CRP, t-PA and LDL-C are established indicators of risk for CVD, which reduced in patients with periodontitis after scaling and root planning. Our findings are consistent with those reported in literature.(13)-(15) Also, plasma t-PA levels was increased in periodontitis patients. Increased plasma t-PA level is a marker of endothelial dysfunction, and has been associated with increased risk of CHD.(8)-(9) Endothelial dysfunctions has been reported to be associated with increased risk for atherosclerosis in healthy patients, and have been considered to be valuable in the early stages, before manifestations or formation of atherosclerotic plaque. Following treatment, the tPA levels fell significantly, and plasma LDL cholesterol levels were higher in these patients and reduced following treatment. To the best of our knowledge, this is the first study reporting the effect of scaling and root planning in periodontitis, to decrease LDL-C, tPA and CRP levels.
Since the number of patients in this study was relatively small, these results need to be interpreted with caution. Nevertheless, these results are compatible with the view that only “susceptible” individuals react to periodontitis with increase t-PA, CRP and LDC-C, and that these individuals were not necessarily the ones with the most severe disease. Treating periodontitis by scaling and root planning lowered t-PA, CRP and LDL-C levels in these individuals, which could also possibly reduce their CHD risk. It may be concluded that biomarkers of inflammation ie. dyslipidaemia and endothelial dysfunction, rather than haemostatic factors, may be potential medicators of the periodontal cardiovascular disease relationship. The extent to which the control of periodontal infections results in lower incidence of CHD, needs to be addressed in future studies.
We are thankful to Jain Diagnostic Centre, New Delhi for Sponsorship and caring out the lab investigations and Dr.Jasdeep Kaur, Resident, BJS dental College, LDH, 162 Kapurthala (member of our group) for helping during study
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase
- EBSCOhost
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)
- www.omnimedicalsearch.com