Case report
Long-term Outcome in Neuroendocrine Tumour of the Prostate: A Rare Case Report with Literature Review
XD01-XD03
Correspondence
Dr. Laxman Pandey,
Department of Radiation Oncology, Rohilkhand Cancer Institute, Rohilkhand Medical College and Hospitals Campus, Pilibhit Bypass Road, Bareilly-243006, Uttar Pradesh, India.
E-mail: laxmanpnd06@gmail.com
Neuroendocrine (NE) prostate cancer is a rare and aggressive variant of prostate carcinoma, often presenting in advanced stages with widespread metastases and is associated with poor prognosis and limited treatment options. Hereby, the authors present the case of a 66-year-old male initially diagnosed with metastatic adenocarcinoma of the prostate with NE differentiation. Despite a normal Prostate-Specific Antigen (PSA) level, extensive metastatic disease involving lymph nodes, liver and bones was identified. The patient was treated with systemic chemotherapy (cisplatin and etoposide) and palliative radiotherapy. Subsequent progression led to brain metastases and bony metastasis, which were managed with whole brain radiotherapy and systemic second line chemotherapy. The patient tolerated treatment well and remains asymptomatic on follow-up. NE prostate cancer is a rare and aggressive entity with limited therapeutic options. Normal PSA levels in the setting of advanced disease should raise suspicion for NE differentiation. Early diagnosis and aggressive multimodal therapy, including high-dose radiotherapy, may improve symptom control and prolong survival in selected patients.