Early Outcome of Platelet Rich Plasma and Non-steroidal Anti-inflammatory Agent Alone and in Combination on Primary Knee Osteoarthritis
RC06-RC08
Correspondence
Dr. Oluwadare Esan,
Department of Orthopaedic Traumatology, Faculty of Clinical Sciences, Ile-Ife, Osun, Nigeria.
E-mail: seunkayo@yahoo.com
Introduction: Platelet rich plasma is an emerging treatment modality in managing mild and moderate cases of osteoarthritis. There is no consensus on dose and various combination of this product with other available treatment modalities especially Non-Steroidal Anti-Inflammatory Drugs (NSAID).
Aim: To determine and compare the early treatment outcomes of intra-articular injection of Platelet Rich Plasma (PRP) and oral NSAIDs alone and in combination in mild and moderate knee osteoarthritis.
Materials and Methods: Forty-five subjects with mild and moderate osteoarthritis who met the study criteria were randomly allocated into three intervention groups: Group A: had intra-articular injections of autologous PRP only; Group B: received oral NSAIDs only, while Group C: had both oral NSAID and intra-articular injection of autologous PRP. Subjects in Group A had 3 sessions of injections at monthly interval while Group B had 75 mg of Diclofenac taken daily at 8 am and 8 pm. Subjects in the Group C had both monthly injections of autologous PRP and oral administration of NSAIDs for three months. Outcome measures were severity of pain assessed using Visual Analogue Scale (VAS) and functional outcome using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Data were analysed using the IBM SPSS Statistics Version 22, Armonk, NY; IBM Corp and Comparison of the means were done using analysis of variance (ANOVA).
Results: Better responses in the severity of pain and functional outcome were seen in subjects who had intra-articular administration of autologous platelet rich plasma with or without NSAIDs than in subjects who had only NSAIDs (p<0.05).
Conclusion: PRP alone and in combination with NSAID is superior to NSAID only therapy in mild and moderate osteoarthritis.