Evaluation of Nexus of Dental Erosion and Gastro-esophageal Reflux Disease: A Hospital-based Cross-sectional Study
ZC17-ZC20
Correspondence
Manoj Mahadeo Ramugade,
Room No. 101, Government Dental College and Hospital, Mumbai, Maharashtra, India.
E-mail: manojmds05@yahoo.co.in
Introduction: Oral Squamous Cell Carcinoma (OSCC) accounts for approximately 90% of all the oral malignancies and a major cause of morbidity and mortality worldwide. The study utilises the Anneroth’s multifactorial grading system with Argyrophilic Nucleolar Organiser Region (AgNOR) score and the p53 expression as adjuncts; emphasising on the enhanced efficiency rendered by nuclear proliferative indices is the gold standard method of histomorphological grading of OSCC.
Aim: To analyse the relationship between the histomorphological grading (Anneroth’s grading) and the nuclear proliferative markers that is AgNOR and p53 protein in OSCC.
Materials and Methods: Total 98 cases of OSCC were investigated from July 2017 to July 2019. The histomorphological grading was done according to the Anneroth’s system. The AgNOR score was quantified by counting the mean number of AgNORs per cell. The p53 expression was graded as score 0 to 3 according to the percent of cells showing positive p53 immunostaining.
Results: An increasing trend in the mean AgNOR count and p53 expression was observed with progressing histological grade of OSCC.
Conclusion: The nuclear proliferative indices (AgNORs and p53) serve as reliable predictive markers and can be used as an adjunct to the gold standard Anneroth’s histomorphological grading system of OSCC.