Acquired Inhibitor of Factor VIII Presenting as Delayed Wound Healing ED21-ED23
Dr. Sushma Nayar,
Associate Professor, Department of Pathology, Chettinad Hospital and Research Institute, Rajiv Gandhi Salai,
Kelambakkam, Kanchipuram District, Chennai-603103, Tamil Nadu, India.
Acquired coagulation factor VIII inhibitor leads to a rare disease i.e., acquired haemophilia which is idiopathic in majority of cases and is seen with autoimmune diseases, haematologic and solid tumours, infections, in the post-partum period and also with certain long-term use of drugs like penicillin and its derivatives, phenytoin, sulfa antibiotics, chloramphenicol, methyldopa, chlorpromazine, levodopa, interferon-a, fludarabine, clopidogrel. We report a case here, with acquired Factor VIII (FVIII) inhibitor acquisition which presented with delayed wound healing as a result of protracted bleeding into the wound. The inhibitor was acquired due to prolonged chlorpromazine use.